{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:03:14Z","timestamp":1784343794553,"version":"3.55.0"},"reference-count":162,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) induced by medication\u2010related toxicity is a significant health concern in contemporary healthcare systems. Gentamicin, a potent aminoglycoside antibiotic crucial for managing serious Gram\u2010negative bacterial infections, is a prominent risk factor due to its accumulation in the renal cortex, which often leads to renal toxicity. In addition to direct tubular damage from selective uptake of gentamicin by the megalin\/cubilin receptor complex, intrinsic signaling pathways associated with gentamicin\u2010induced AKI, including lysosomal rupture, mitochondrial dysfunction, and reactive oxygen species production, exacerbate the development and severity of the condition. The mechanisms underlying and preventing gentamicin\u2010induced nephrotoxicity remain poorly understood, despite extensive research. Recent developments in regulated cell death (RCD) offer novel insights. This review seeks to clarify the growing significance and fundamental molecular mechanisms of RCD pathways in gentamicin\u2010induced AKI. A better understanding of the mechanisms governing cell death in gentamicin\u2010induced nephrotoxicity may facilitate the development of effective therapeutic options.<\/jats:p>","DOI":"10.1002\/jat.70349","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:40:29Z","timestamp":1784342429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights Into Regulated Cell Death Pathways in Gentamicin\u2010Induced Nephrotoxicity: Molecular Mechanisms and Future Perspectives"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3836-4098","authenticated-orcid":false,"given":"Islam Ahmed","family":"Abdelmawgood","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Biotechnology\/Biomolecular Chemistry Program, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Gamal","sequence":"additional","affiliation":[{"name":"Biotechnology\/Biomolecular Chemistry Program, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Hesham","sequence":"additional","affiliation":[{"name":"Biotechnology\/Biomolecular Chemistry Program, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Ali","family":"Gouda","sequence":"additional","affiliation":[{"name":"Biotechnology Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Magdy","sequence":"additional","affiliation":[{"name":"Biotechnology\/Biomolecular Chemistry Program, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engy","family":"Amr","sequence":"additional","affiliation":[{"name":"Biotechnology\/Biomolecular Chemistry Program, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Hazem","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Children's Cancer Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201006355\u20105"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12534"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2016.1165120"},{"issue":"28","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD P30 Elicited by Caspase\u201011 During Pyroptosis Forms Pores in Membranes","volume":"113","author":"Aglietti R. 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