{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:39Z","timestamp":1790812719906,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Male infertility is an increasing global health concern with multifactorial origins. Recent evidence highlights air pollution as a key environmental risk factor affecting male reproductive health. This review synthesises studies from 2020 to 2026 on how airborne pollutants including particulate matter, gaseous compounds, polycyclic aromatic hydrocarbons and microplastics induce oxidative stress and impair testicular function. Oxidative damage emerges as a central mechanism driving mitochondrial dysfunction, inflammation, antioxidant depletion and DNA damage. Epidemiological findings consistently link higher pollutant exposure to reduced sperm quality including count, motility, morphology and genetic integrity. Experimental studies further demonstrate disruption of the blood\u2013testis barrier, apoptosis of germ cells, hormonal imbalance and impairment of the hypothalamic\u2013pituitary\u2013testicular axis. Despite strong mechanistic insights, gaps remain in dose\u2013response relationships, pollutant interactions and long\u2010term reproductive outcomes. This review emphasises the need for integrated strategies combining pollution control, clinical monitoring and antioxidant interventions to mitigate reproductive risks.<\/jats:p>","DOI":"10.1002\/jat.70352","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:52:40Z","timestamp":1784364760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxidative Stress Induced by Air Pollutants and Its Role in Testicular Dysfunction"],"prefix":"10.1002","author":[{"given":"Ayodele Thomas","family":"Fatoba","sequence":"first","affiliation":[{"name":"Department of Animal Production and Health Olusegun Agagu University of Science and Technology  Okitipupa Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotimi Adewale","family":"Olorunsola","sequence":"additional","affiliation":[{"name":"Department of Animal Production and Health Olusegun Agagu University of Science and Technology  Okitipupa Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith Ufuoma","family":"Odiase","sequence":"additional","affiliation":[{"name":"Department of Biology Asoro Grammar School  Benin City Edo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-8851","authenticated-orcid":false,"given":"Thompson Faraday","family":"Ediagbonya","sequence":"additional","affiliation":[{"name":"Faculty of Environmental Studies Lay University of Adventist Kigali  Rwamagana Rwanda"},{"name":"Department of Chemical Science Olusegun Agagu University of Science and Technology  Okitipupa Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.581838"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP12627"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132330"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crtox.2026.100286"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2022.901798"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2368"},{"key":"e_1_2_16_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jobe.2025.112583","article-title":"Comparative Assessment of Total Petroleum Hydrocarbon Levels in Indoor and Outdoor Dust: Implications for Environmental and Human Health","volume":"106","author":"Ediagbonya T. 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