{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:59:11Z","timestamp":1785121151262,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>I read with interest the systematic review by Meamar et\u00a0al. on intravenous lipid emulsion (ILE) therapy for beta\u2010blocker toxicity. I highlight two important issues that may further refine the interpretation of ILE efficacy. First, although no association was observed between ILE dose and cardiovascular outcomes, the optimal dosing regimen for nonlocal anesthetic drug toxicity remains uncertain because current practice is largely extrapolated from local anesthetic systemic toxicity despite important pharmacokinetic differences. Second, drug lipophilicity should be evaluated using the distribution coefficient (log D), rather than the octanol\/water partition coefficient (log P), because log D reflects pH\u2010dependent ionization under physiological conditions. As metabolic acidosis accompanying severe beta\u2010blocker poisoning reduces log D, the lipid shuttle effect may diminish, potentially increasing the relative contribution of ILE's direct cardiotonic and metabolic effects. These considerations suggest that early ILE administration may be advantageous and that log D may better predict responsiveness to ILE than log P. Further studies are warranted to establish optimal dosing strategies and validate the clinical relevance of log D.<\/jats:p>","DOI":"10.1002\/jat.70372","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:02:07Z","timestamp":1785117727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid Emulsion Dosing Regimens and the Influence of Beta\u2010Blocker Lipid Solubility on Lipid Emulsion Resuscitation for Beta\u2010Blocker Toxicity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0102-5800","authenticated-orcid":false,"given":"Ju\u2010Tae","family":"Sohn","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Gyeongsang National University College of Medicine, Gyeongsang National University Hospital  Jinju\u2010si Gyeongsangnam\u2010do Republic of Korea"},{"name":"Institute of Medical Science Gyeongsang National University  Jinju\u2010si Gyeongsangnam\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"issue":"2","key":"e_1_2_1_8_2_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.annemergmed.2015.01.020","article-title":"Confusion About Infusion: Rational Volume Limits for Intravenous Lipid Emulsion During Treatment of Oral Overdoses","volume":"66","author":"Fettiplace M. 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M.","year":"2018","journal-title":"Regional Anesthesia and Pain Medicine"},{"issue":"6","key":"e_1_2_1_8_12_1","doi-asserted-by":"crossref","first-page":"e742","DOI":"10.1097\/MJT.0000000000001300","article-title":"Lipid Emulsion Treatment of Nonlocal Anesthetic Drug Toxicity","volume":"28","author":"Ok S. H.","year":"2020","journal-title":"American Journal of Therapeutics"},{"issue":"1","key":"e_1_2_1_8_13_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4097\/kja.23825","article-title":"Lipophilicity of Drugs, Including Local Anesthetics, and Its Association With Lipid Emulsion Resuscitation","volume":"77","author":"Wiedmer S. K.","year":"2024","journal-title":"Korean Journal of Anesthesiology"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.70372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:02:10Z","timestamp":1785117730000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.70372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":12,"alternative-id":["10.1002\/jat.70372"],"URL":"https:\/\/doi.org\/10.1002\/jat.70372","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]},"assertion":[{"value":"2026-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jat.70372"}}