{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:13:32Z","timestamp":1786115612499,"version":"build-2736575974"},"reference-count":159,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>E\u2010cigarette devices emit ultrafine metal\u2010containing particles from heating coils, solder joints, and other wetted components, but their reproductive toxicology remains poorly defined. This review integrates evidence from aerosol chemistry, nanoparticle toxicology, and male reproductive biology to evaluate whether these particles may contribute to male reproductive dysfunction through mitochondrial injury. E\u2010cigarette aerosols can contain nanoscale and ultrafine particles bearing chromium, nickel, iron, copper, zinc, tin, and lead. These particles may deposit in the distal lung and, based on broader nanoparticle toxicokinetics, could enter the systemic circulation. However, direct particle\u2010resolved evidence of their accumulation in testicular tissue is currently absent. Mechanistic evidence therefore derives mainly from engineered nanoparticle and soluble\u2010metal models. These studies indicate that metal exposure can disrupt blood\u2013testis barrier integrity, impair Sertoli\u2010 and Leydig\u2010cell function, alter steroidogenesis, damage germ cells, and reduce sperm quality. Mitochondria represent a plausible point of convergence because particle\u2010 and ion\u2010mediated mechanisms can promote mitochondrial reactive oxygen species generation, lipid peroxidation, respiratory dysfunction, mitochondrial DNA damage, altered fusion\u2013fission balance, defective mitophagy, apoptosis, and inflammatory signaling. These pathways provide a biologically plausible framework linking inhaled metal\u2010containing particles to impaired spermatogenesis and steroidogenesis, without establishing causality under realistic vaping conditions. Future studies should combine inhalation\u2010relevant exposure models with particle\u2010resolved biodistribution, dosimetry, and mechanistic reproductive endpoints to determine whether these pathways operate following e\u2010cigarette exposure.<\/jats:p>","DOI":"10.1002\/jat.70382","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T03:45:13Z","timestamp":1785987913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Mechanisms in the Potential Male Reproductive Toxicity of E\u2010Cigarette\u2010Derived Metal\u2010Containing Nanoparticles"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8994-2793","authenticated-orcid":false,"given":"Ardie Barry","family":"Sailis","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c01005"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/128319"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.08.014"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010024\u201004330\u20101"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep\u201019\u20100452"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5c08370"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696\u2010021\u201001779\u20105"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1063916"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010022\u201000480\u2010z"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010021\u201002763\u20106"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5BM00387C"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060929"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44324\u2010024\u201000045\u2010y"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.139155"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401132"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00271C"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071490"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007095"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.07.014"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6mt00150e"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.113039"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108292"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103195"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.25"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.impact.2024.100517"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110023"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5c00178"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apt.2013.10.010"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2016.1163448"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201007786\u20108"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001338\u20104"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/sym14040767"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147880"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1273177"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.11.002"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13070609"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00010\u201019"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201040579\u20106"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00133"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010057"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkaa185"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010022\u201000467\u2010w"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007628"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201003463\u20108"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa089"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.24.7.2593\u20102604.2004"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201022\u20103047"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114598"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma3104842"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijnS14363"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11020155"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2025\u20108449"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr319"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.4c00033"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116032"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201056872\u20103"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02273"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039393\u20106"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19031892"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.impact.2021.100350"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2017.1306894"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.14.28"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.24559"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/tc\u20102024\u2010058915"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102519"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010023\u201000515\u2010z"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010018\u20100341\u20102"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.06.109"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR02153B"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1457985"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007047107"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010021\u201014853\u2010y"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010023\u201001267\u20101"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002672\u20105"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117446"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR05407D"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010020\u201002404\u20104"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.4161\/spmg.22602"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/942916"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030663"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113114"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/02786826.2018.1513636"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlrR016675"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030703"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1183592"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.04.001"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/08958378.2020.1840678"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14111276"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00389.2021"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.14.10.637"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1201198"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203763"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijnS415063"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21325"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp2175"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26199301"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkaa088"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070728"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5280"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121365"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.05.020"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111557"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102122"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011104"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010019\u20100302\u20108"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010090"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2025.100750"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2026.2658739"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010026\u201004486\u2010w"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2025.154339"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhip.2024.100506"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.5c00641"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.7508\/nmj.2016.01.001"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13030767"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20103155\u201011\u201026"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14111455"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.06.013"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411687"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae077"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.008"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20105793(94)80582\u20102"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176152"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn505399e"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc\/174583"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.235937"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.129845"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158061"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010024\u201001204\u2010y"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI193793"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijnS170723"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c03032"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010022\u201004134\u20103"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1520835"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2023.103984"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043896"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010025\u201001180\u20102"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntaa193"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057987"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051\u2010019\u20104598\u2010y"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20289"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102554\u20105"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15152246"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.915274"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005364\u2010w"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200217666160105111436"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.01.001"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114827"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131208"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijnS230949"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1080\/08958378.2020.1776801"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.032"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1001572"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp5686"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111060"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005740\u20104"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14080689"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.02.067"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.272278.115"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.103653"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.70382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T03:45:17Z","timestamp":1785987917000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.70382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":159,"alternative-id":["10.1002\/jat.70382"],"URL":"https:\/\/doi.org\/10.1002\/jat.70382","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jat.70382"}}