{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:23:34Z","timestamp":1787538214288,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cardiovascular diseases are increasingly linked to environmental toxicants, including widely used organophosphate pesticides. This study investigates the cardiotoxic potential of chlorpyrifos (CPF) and dimethoate (DM) using complementary in\u00a0vivo and in\u00a0vitro models. Female Wistar rats were orally exposed to CPF, DM and their combination for 30\u2009days. Histopathological analyses revealed myocardial disarray, interstitial edema, inflammatory infiltration and aortic endothelial disruption, with combination group showing the most severe injury. Haematological alterations including reduced RBC and haemoglobin, elevated leukocyte and platelet counts were accompanied by significantly increased hydroxyproline content in heart and aorta, indicating early fibrotic remodelling. Molecular analysis demonstrated marked upregulation of NF\u2010\u03baB, NLRP3, IL\u20101\u03b2, IL\u201018 and TNF\u2010\u03b1, along with suppression of eNOS, confirming activation of NF\u2010\u03baB\/NLRP3 inflammasome axis and endothelial dysfunction. In\u00a0vitro, CPF but not DM reduced endothelial cell viability and induced ROS generation and lactate dehydrogenase (LDH) release in HUVECs. CPF also elevated inflammatory and cell adhesion markers while downregulating eNOS and tight\u2010junction proteins. Notably, NLRP3 inhibition by MCC950 mitigated CPF\u2010induced inflammatory signaling and restored endothelial function. Collectively, these findings demonstrate that CPF and DM exposure induces cardiovascular injury mediated through oxidative stress, inflammasome activation and nitric oxide dysregulation, highlighting NLRP3 as a potential therapeutic target in pesticide\u2010associated vascular toxicity.<\/jats:p>","DOI":"10.1002\/jat.70388","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T01:49:45Z","timestamp":1787536185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organophosphate Pesticides Promote Cardiovascular Toxicity via NF\u2010\u03baB\/NLRP3 Inflammasome Activation and Endothelial Dysfunction: Integrated In\u00a0Vivo and In\u00a0Vitro Evidence"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9106-215X","authenticated-orcid":false,"given":"Jasmeena","family":"Jan","sequence":"first","affiliation":[{"name":"Department of Biotechnology, School of Life Sciences Central University of Kashmir  Ganderbal Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6736-073X","authenticated-orcid":false,"given":"Salman","family":"Shamas","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Life Sciences Central University of Kashmir  Ganderbal Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajid Mohammad","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry Sher\u2010E\u2010Kashmir University of Agricultural Sciences and Technology  Srinagar Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0983-5157","authenticated-orcid":false,"given":"Showkeen Muzamil","family":"Bashir","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry Sher\u2010E\u2010Kashmir University of Agricultural Sciences and Technology  Srinagar Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3594-2221","authenticated-orcid":false,"given":"Abid Hamid","family":"Dar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Life Sciences Central University of Kashmir  Ganderbal Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Afzal","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Life Sciences Central University of Kashmir  Ganderbal Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owais Mohmad","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Life Sciences Central University of Kashmir  Ganderbal Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-9039","authenticated-orcid":false,"given":"Nissar Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Life Sciences Central University of Kashmir  Ganderbal Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"issue":"7","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e29128","article-title":"Pesticides Impacts on Human Health and the Environment With Their Mechanisms of Action and Possible Countermeasures","volume":"10","author":"Ahmad M. 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