{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:14:24Z","timestamp":1788225264322,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["2210\u2010A"],"award-info":[{"award-number":["2210\u2010A"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6\u2010week\u2010old female BALB\/c mice exposed to 2.5, 5, and 10\u2009mg\/kg\/day intraperitoneally for 14\u2009days. Hepatic changes were assessed via histopathology, ultrastructure, biochemistry, and molecular analyses. BPM caused dose\u2010dependent liver damage, including hydropic degeneration, necrosis, apoptosis, sinusoidal dilatation, and fibrotic remodeling. Masson's trichrome staining indicated increased collagen deposition, especially in medium\u2010 and high\u2010dose groups. TUNEL assay confirmed elevated hepatocyte apoptosis, and immunohistochemistry showed dose\u2010dependent TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 upregulation in hepatocytes, portal areas, and inflammatory regions. Transmission electron microscopy identified mitochondria and endoplasmic reticulum as primary targets, showing mitochondrial swelling, cristae disruption, membrane rupture, myelin figure formation, ribosomal loss, and rough ER disorganization. Biochemically, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and IL\u20106 increased significantly, while tissue sspartate aminotransferase (AST) and alanine aminotransferase (ALT) remained unchanged. Molecular analysis revealed upregulation of\n                    <jats:italic>p53, Bax<\/jats:italic>\n                    ,\n                    <jats:italic>caspase\u20103<\/jats:italic>\n                    , and cytochrome c, indicating activation of the intrinsic mitochondrial apoptotic pathway. Concurrent\n                    <jats:italic>Bcl\u20102<\/jats:italic>\n                    upregulation suggested compensatory anti\u2010apoptotic responses under severe stress. In summary, BPM induces dose\u2010dependent hepatotoxicity associated with mitochondrial, inflammatory, and apoptotic alterations, which may not be reflected by changes in conventional liver enzyme markers, including AST and ALT. These findings raise concerns regarding the safety of BPA alternatives and emphasize the need for careful evaluation of BPM\u2010related health risks.\n                  <\/jats:p>","DOI":"10.1002\/jat.70408","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:30:50Z","timestamp":1788222650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bisphenol M Induces Dose\u2010Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-2397","authenticated-orcid":false,"given":"Muhammed","family":"Canik","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Biology Sakarya University  Serdivan Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-4279","authenticated-orcid":false,"given":"Asuman Deveci","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biology Sakarya University  Adapazar\u0131 Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-0597","authenticated-orcid":false,"given":"Tu\u011fba","family":"Kotil","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Istanbul University  Fatih Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6830-8971","authenticated-orcid":false,"given":"Nazan Deniz","family":"Y\u00f6n","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biology Sakarya University  Serdivan Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201008041\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201012937\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5455\/OVJ.2023.v13.i1.9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.25032"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092136"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2025.126780"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010019\u201004487\u20106"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146905"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22642"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108667"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153798"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010675"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2017.9273"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061929"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.22"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/livers5020024"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117385"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.7537\/marslsj100113.106"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/livers5020024"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168\u20108278(95)80226\u20106"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wasman.2024.03.010"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134681"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.10.074"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010511"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/901983"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100740200"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098\u2010017\u20102595\u20107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.125186"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054585"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164748"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2020.104959"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23148042"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114610"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17134793"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.22038\/AJP.2021.17649"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.112658"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.21608\/eajbsd.2021.159174"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30771"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105811"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.02.148"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/54.1.3"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/07482337241233312"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijabmr.IJABMR_663_20"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2021.1950179"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278\u20106915(03)00031\u20100"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.7603\/s40730\u2010014\u20100009\u20102"},{"key":"e_1_2_11_48_1","unstructured":"University of Pittsburgh Medical Center (UPMC).2025. \u201c13 September. mHAI Schema. TPIS Library.\u201dhttps:\/\/tpis.upmc.com\/tpislibrary\/schema\/mHAI.html."},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109182"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.145301"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118591"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090443"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2022.109275"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.01.036"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/096032711246479"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2023.09.014"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.4552"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.70408","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:30:54Z","timestamp":1788222654000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.70408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":56,"alternative-id":["10.1002\/jat.70408"],"URL":"https:\/\/doi.org\/10.1002\/jat.70408","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jat.70408"}}