{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:56:28Z","timestamp":1790553388389,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    BPA is an endocrine\u2010disrupting molecule that is ubiquitously found in the environment. Epidemiological studies have shown that BPA exposure to humans during the early stage life is linked to renal dysfunction, including albuminuria, proteinuria, increased serum creatinine, and electrolyte imbalances. BPA alters the endocrine axis; however, BPA\u2010mediated endocrine disruption has already been documented, and its cellular mechanism underlying developmental toxicity is not well defined. In the present study, we examined the effect of dietary BPA exposure on the developing renal organs of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    larvae. BPA exposure significantly elevated ROS and lipid peroxidation, and depletion of key antioxidant enzymes, including SOD, CAT, and GSH, was observed, along with mitochondrial dysfunction, including a reduction in MMP and ATP levels, which indicate impaired bioenergetic capacity. Structural analyses revealed the disruption of cytoskeletal proteins F\u2010actin and dlg, as well as progressive tubule hypertrophy. At the molecular level, transcriptional elevation of components related to the Nrf2\u2010mediated stress response was observed, while transporter genes showed altered expression patterns, suggesting impaired detoxification capacity. Altogether, these findings demonstrate that early\u2010stage exposure to BPA induces oxidative stress\u2010associated mitochondrial dysfunction, transporter dysregulation, and cytoskeletal remodeling in MTs. Collectively, these results define oxidative stress\u2010associated molecular, cellular and structural alterations underlying BPA\u2010induced nephrotoxicity and demonstrate\n                    <jats:italic>Drosophila<\/jats:italic>\n                    as a mechanistically informative model for developmental toxicology research.\n                  <\/jats:p>","DOI":"10.1002\/jat.70411","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:36:16Z","timestamp":1790552176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Bisphenol\u2010A Exposure Induces Oxidative Stress\u2013Mediated Developmental Renal Toxicity in\n                    <scp>\n                      <i>Drosophila melanogaster<\/i>\n                    <\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9392-6156","authenticated-orcid":false,"given":"Poornima","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-4344","authenticated-orcid":false,"given":"Naveen Kumar","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjoy Kumar","family":"Sureka","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-5014","authenticated-orcid":false,"given":"Neha","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amisha","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Sagar","sequence":"additional","affiliation":[{"name":"Analytical Sciences and Accredited Testing Services Group, Analytical Sciences and Services, Industrial Support through Technological Solutions (ASSIST) Division, CSIR\u2010Indian Institute of Toxicology Research (CSIR\u2010IITR), Vishvigyan Bhawan Campus  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-5500","authenticated-orcid":false,"given":"Somendu kumar","family":"Roy","sequence":"additional","affiliation":[{"name":"Analytical Sciences and Accredited Testing Services Group, Analytical Sciences and Services, Industrial Support through Technological Solutions (ASSIST) Division, CSIR\u2010Indian Institute of Toxicology Research (CSIR\u2010IITR), Vishvigyan Bhawan Campus  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-0161","authenticated-orcid":false,"given":"M. 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