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This study aimed to determine whether prolonged exposure to benzo[a]pyrene (B[a]P) and catechol (CL) enhanced malignant phenotypes in human lung cancer A549 cells. Following 3\u2009months of exposure plus an additional month of maintenance culture, cells treated with either pollutant exhibited persistently increased migration, invasion, and colony formation. Integrated transcriptomic and proteomic profiling revealed consistent upregulation of extracellular matrix remodeling and glycolytic pathways. Among the commonly elevated targets, four showing the most significant upregulation (\n                    <jats:italic>LOX<\/jats:italic>\n                    ,\n                    <jats:italic>CLDN1<\/jats:italic>\n                    ,\n                    <jats:italic>HK2<\/jats:italic>\n                    , and\n                    <jats:italic>SLC2A1<\/jats:italic>\n                    , with the latter encoding GLUT1) were identified and verified by qRT\u2010PCR and western blotting. Knockdown of each candidate markedly reduced the pollutant\u2010induced migratory and invasive capacities, with GLUT1 silencing showing the strongest effect. Moreover, high expression of these four genes correlated with worse survival outcomes in lung cancer patients. Collectively, these results indicated that chronic exposure to structurally distinct pollutants promoted lung cancer invasion through convergent upregulation of LOX, CLDN1, HK2, and GLUT1, highlighting them as potential prognostic biomarkers and therapeutic targets.\n                  <\/jats:p>","DOI":"10.1002\/jat.70462","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:32:57Z","timestamp":1790746377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Exposure to Benzo[a]pyrene and Catechol Drives Lung Cancer Invasion via Convergent Extracellular Matrix Remodeling and Metabolic Reprogramming"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2417-726X","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University 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