{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:53:58Z","timestamp":1791006838748,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22306203"],"award-info":[{"award-number":["22306203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22276216"],"award-info":[{"award-number":["22276216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB157"],"award-info":[{"award-number":["2024AFB157"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent environmental endocrine\u2010disrupting chemicals that can cross the placental barrier and may disrupt fetal thyroid homeostasis; however, the sex\u2010specific thyroid toxicity of PFAS remains poorly characterized. This study recruited 247 mother\u2013infant pairs from a tertiary hospital in Wuhan, China, and measured PFAS concentrations in maternal and cord serum. The results showed that perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonate (PFHxS) were the predominant PFAS in both maternal and cord serum. Their median concentrations were 5.520, 3.896, and 4.154\u2009ng\/mL in maternal serum, respectively, and 7.112, 2.704, and 2.422\u2009ng\/mL in cord serum, respectively. Several short\u2010chain PFAS, including perfluoropentanoic acid (PFPeA), perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), and perfluoropentane sulfonic acid (PFPeS), exhibited relatively high transplacental transfer efficiency (TTE). PFAS with a cord serum detection rate &gt;\u200990% were selected for subsequent analyses. Spearman correlation analysis showed strong coexposure patterns among several long\u2010chain PFCAs, with the strongest correlations observed among PFDA, PFNA, and PFUdA (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.81\u20130.89,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). PFAS\u2013thyroid hormone correlations were generally weak; only PFHpS was inversely correlated with TSH (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.16,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). In multivariable linear regression models, PFHxS was positively associated with TSH in the overall sample (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.085,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), whereas PFHxA was inversely associated with FT4 (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.106,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Among female newborns, GenX was inversely associated with TSH (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22129.411,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), whereas PFHxS was positively associated with TSH (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.109,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Among male newborns, PFDA (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.132,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), PFHxA (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.137,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), PFNS (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.287,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and PFOS (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.029,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) were inversely associated with FT4. No individual PFAS was significantly associated with FT3. Formal interaction analysis showed evidence of sex heterogeneity for the PFNS\u2013FT4 association (\n                    <jats:italic>P<\/jats:italic>\n                    for interaction\u2009=\u20090.008). Qgcomp showed nonsignificant overall mixture effects for FT3, FT4, and TSH. Similarly, BKMR showed no statistically significant overall mixture effects or individual PFAS associations with thyroid hormone levels.\n                  <\/jats:p>","DOI":"10.1002\/jat.70469","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:16:37Z","timestamp":1791004597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental Transfer of PFAS and Their Sex\u2010Specific Associations With Neonatal Thyroid Hormones in a Chinese Birth Cohort"],"prefix":"10.1002","author":[{"given":"Shuhan","family":"Li","sequence":"first","affiliation":[{"name":"School of Engineering China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Zhongnan Hospital of Wuhan University  Wuhan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9916-8531","authenticated-orcid":false,"given":"Yanhua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Engineering China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-6865","authenticated-orcid":false,"given":"Jianqiu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Engineering China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.104929"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c03578"},{"key":"e_1_2_9_4_1","volume-title":"Endotext","author":"Bernal 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