{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:49:19Z","timestamp":1791971359498,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/08846\u20105"],"award-info":[{"award-number":["2022\/08846\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The effects of anabolic steroid abuse on the cardiac tissue of resistance training practitioners are poorly understood. Herein, we present the histomorphometric implications of resistance training in rats treated with nandrolone decanoate, an androgenic anabolic steroid. Eighteen\u2010week\u2010old male Wistar rats (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200932) were divided into two groups (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200916): vehicle group (VEH; 0.2\u2009mL\/kg i.m., peanut oil) and group treated with nandrolone decanoate (NAN; 5\u2009mg\/kg i.m.), both for 12\u2009weeks. Half of each group underwent a resistance training protocol (VEH\u2010T and NAN\u2010T) during the same period. At the end, the animals were euthanized for cardiac morphometric and histological evaluation. The NAN group presented an increase in left ventricular wall thickness and cardiomyocyte cross\u2010sectional area, together with a reduction in the percentage area occupied by cardiomyocytes and an increase in interstitial fibrosis percentage, compared with the VEH group. In turn, the VEH\u2010T group showed increased left ventricular wall thickness, cardiomyocyte cross\u2010sectional area, and myonuclear number, with no effect on interstitial fibrosis or the percentage area occupied by cardiomyocytes. In contrast, the NAN\u2010T group exhibited a higher cardiomyocyte cross\u2010sectional area and myonuclear number than the other groups, together with a lower interstitial fibrosis percentage than the NAN group. Chronic treatment with a supraphysiological dose of nandrolone decanoate resulted in adverse cardiac remodeling and increased interstitial fibrosis. Resistance training promoted cardiac hypertrophy without increasing fibrosis. When combined with nandrolone, training was associated with lower fibrosis values than those observed in untrained nandrolone\u2010treated animals but did not prevent the major structural alterations associated with nandrolone exposure.\n                  <\/jats:p>","DOI":"10.1002\/jat.70478","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:02:11Z","timestamp":1791968531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Histomorphometric Implications Resulting From Chronic Nandrolone Decanoate Treatment in Rats Subjected to Resistance Training"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-0701","authenticated-orcid":false,"given":"Lucas D.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6282-0848","authenticated-orcid":false,"given":"Tallys E.","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-733X","authenticated-orcid":false,"given":"Bruno A.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6527-2304","authenticated-orcid":false,"given":"Jo\u00e3o V. M.","family":"Bernal","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0720-014X","authenticated-orcid":false,"given":"Gabriel A.","family":"Lavez","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3557-4344","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Passaglia","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-0005","authenticated-orcid":false,"given":"Hugo C. D.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010024\u201001611\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0022\u20104707.18.08366\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102012\u2010091186"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.222330"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101681.2005.04180.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2007.707"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(03)00687\u20101"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2011.595714"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017839"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2025.133896"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001153\u20101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12576\u2010023\u201000868\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004473"},{"key":"e_1_2_9_15_1","unstructured":"Corulli M. 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