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This study evaluated metal concentrations in water, sediment, and tissues of 10 fish species from different trophic guilds in the Paraopeba River after the Brumadinho dam collapse. Multivariate analyses (principal component analysis [PCA], generalized linear model [GLM], and PERMANOVA) were used to explore associations between metal concentrations, ecological traits, and body size integrated with liver histopathology (Histopathological Alteration Index) and Human Health Risk Assessment. Results revealed that metal concentrations in water and fish tissues exceeded regulatory limits, whereas sediment acted as the main reservoir of metals, exhibiting higher concentrations than water. High\u2010severity liver damage was concentrated in benthic piscivores and benthopelagic detritivores, exposing a complex interplay between biomagnification and direct substrate contact. Human Health Risk Assessments indicated unacceptable noncarcinogenic risks driven by aluminum (Al), along with elevated carcinogenic risks for chromium (Cr) and cadmium (Cd) for both adults and children in the region analyzed. These findings demonstrate that ecological traits were associated with differences in metal accumulation, liver damage, and public health threats, reinforcing the need for nonlinear models in postdisaster regulatory frameworks.<\/jats:p>","DOI":"10.1002\/jat.70479","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:31:03Z","timestamp":1792477863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metal Accumulation, Liver Histopathology, and Human Health Risk Assessment Across Different Trophic Guilds in a Mining\u2010Affected Neotropical River"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1961-7379","authenticated-orcid":false,"given":"Breno","family":"Thuller","sequence":"first","affiliation":[{"name":"Graduate Program in Biodiversity and Environment Pontifical Catholic University of Minas Gerais \u2010 PUC Minas  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-0062","authenticated-orcid":false,"given":"Alessandro Loureiro","family":"Paschoalini","sequence":"additional","affiliation":[{"name":"Graduate Program in Biodiversity and Environment Pontifical Catholic University of Minas Gerais \u2010 PUC Minas  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Pereira","family":"Arantes","sequence":"additional","affiliation":[{"name":"Graduate Program in Biodiversity and Environment Pontifical Catholic University of Minas Gerais \u2010 PUC Minas  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-9017","authenticated-orcid":false,"given":"Cristiano Schetini de","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Biodiversity, Evolution and Environment, Morro do Cruzeiro Campus, s\/n, Bauxita Institute of Exact and Biological Sciences, Federal University of Ouro Preto \u2010 UFOP  Ouro Preto Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-0856","authenticated-orcid":false,"given":"Elizete","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences Federal University of Minas Gerais \u2010 UFMG  Ant\u00f4nio Carlos Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-4927","authenticated-orcid":false,"given":"Nilo","family":"Bazzoli","sequence":"additional","affiliation":[{"name":"Graduate Program in Biodiversity and Environment Pontifical Catholic University of Minas Gerais \u2010 PUC Minas  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/26395940.2025.2608455"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2166\/wpt.2022.039"},{"key":"e_1_2_12_4_1","unstructured":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (ANVISA).2022. \u201cInstru\u00e7\u00e3o Normativa n\u00b0 160 de 1\u00b0 de julho de 2022: Estabelece os limites m\u00e1ximos tolerados de contaminantes em alimentos.\u201d Bras\u00edlia ANVISA."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.17582\/journal.pjz\/20220223170218"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10807039.2018.1438175"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","DOI":"10.1201\/9781439833544","volume-title":"Geochemistry, Groundwater and Pollution","author":"Appelo C. 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