{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:49:46Z","timestamp":1761893386907,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,10,4]],"date-time":"2001-10-04T00:00:00Z","timestamp":1002153600000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a concern that oral treatment with succimer (<jats:italic>meso<\/jats:italic>\u20102, 3\u2010dimercaptosuccinic acid, DMSA) can promote gastrointestinal lead absorption if not performed in a lead\u2010safe environment. The scope of our investigation was to evaluate the efficacy of oral DMSA treatment during oral lead exposure on tissue lead in suckling rats. Six\u2010day\u2010old Wistar rats of both genders were divided into two groups\u2014untreated (Pb) and treated (Pb + DMSA)\u2014with 10 animals per group. Lead (as acetate) was given orally at a dose of 2 mg kg<jats:sup>\u22121<\/jats:sup> body weight day<jats:sup>\u22121<\/jats:sup> for eight consecutive days (total dose 16 mg kg<jats:sup>\u22121<\/jats:sup>, i.e. 0.08 mmol kg<jats:sup>\u22121<\/jats:sup>). During this period the treated group received a daily dose of 0.5 mmol DMSA kg<jats:sup>\u22121<\/jats:sup> body weight p.o. six times on days 1\u20133 and 6\u20138 of the experiment (total dose 3 mmol kg<jats:sup>\u22121<\/jats:sup>). Tissue lead was determined by means of atomic absorption spectrometry. The DMSA efficiently reduced the lead concentration in the analysed tissues (carcass, liver, kidneys and brain) by \u223c50% compared with untreated controls. The pups' growth and organ weights were not affected. In conclusion, our results indicate that DMSA is an efficient oral lead chelator in sucklings even if challenged with ongoing lead exposure. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.772","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:17:12Z","timestamp":1030295832000},"page":"415-416","source":"Crossref","is-referenced-by-count":11,"title":["Succimer treatment during ongoing lead exposure reduces tissue lead in suckling rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Veda Marija","family":"Varnai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Piasek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Blanu\u0161a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Matek Sari\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Kostial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1542\/peds.96.1.155","article-title":"Treatment guidelines for lead exposure in children","volume":"96","author":"Committee on Drugs, American Academy of Pediatrics","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100100945"},{"key":"e_1_2_1_4_2","series-title":"Trace Elements in Man and Animals","first-page":"11.1","author":"Kostial K","year":"1991"},{"key":"e_1_2_1_5_2","first-page":"337","article-title":"Factors influencing the efficiency of chelation therapy","volume":"35","author":"Kostial K","year":"1991","journal-title":"J. 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