{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:45:01Z","timestamp":1761741901353,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,10,4]],"date-time":"2001-10-04T00:00:00Z","timestamp":1002153600000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The measurement of natural killer (NK) cell activity often is recommended as an endpoint for inclusion in the non\u2010clinical immunotoxicity evaluation of environmental chemicals and pharmaceuticals. To date, most data on the impact of immunotoxicants on NK cell activity have been obtained in the rat. Because non\u2010human primates often are used in the safety evaluation of new medicinal products, there is a need to compare chemically induced changes in NK cell activity between rats and primates. In this study, the <jats:italic>in vitro<\/jats:italic> effects of nickel chloride and morphine hydrochloride were investigated on NK cell activity in the rat and the cynomolgus monkey. Despite some species\u2010specific differences in the techniques used, rather similar results were obtained in the two species. At the higher concentration, nickel chloride induced a significant decrease in NK cell activity in the ranges of 21.6\u201324.3% (rat) and 34.4\u201342.2% (monkey), depending on the effector\u2010to\u2010target cell ratio used, and morphine hydrochloride induced a decrease in the ranges of 23.7\u201334.7% (rat) and 59.1\u201368.0% (monkey). These results suggest that NK cell activity can be used as a reliable endpoint for the assessment of immune effects during safety evaluation studies in the cynomolgus monkey. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.776","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:17:12Z","timestamp":1030295832000},"page":"431-434","source":"Crossref","is-referenced-by-count":22,"title":["Compared effects of morphine and nickel chloride on NK cell activity <i>in vitro<\/i> in rats and monkeys"],"prefix":"10.1002","volume":"21","author":[{"given":"Fabienne","family":"Condevaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Guichard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Forichon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Aujoulat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Descotes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,4]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"43819","volume":"62","author":"Federal Register","year":"1997","journal-title":"Toxic Substances Control Act Test Guidelines. 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