{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:35:57Z","timestamp":1772228157750,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T00:00:00Z","timestamp":1032393600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was undertaken to investigate whether treatment with vitamin E protects rat testis from oxidative stress induced by 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin (TCDD). Male rats of Wistar strain were administered TCDD at doses of 1, 10 and 100 ng kg<jats:sup>\u22121<\/jats:sup> body wt. day<jats:sup>\u22121<\/jats:sup> for 45 days. Other groups of animals were co\u2010administered TCDD (1, 10 and 100 ng kg<jats:sup>\u22121<\/jats:sup> body wt. day<jats:sup>\u22121<\/jats:sup>) and vitamin E (20 mg kg<jats:sup>\u22121<\/jats:sup> body wt. day<jats:sup>\u22121<\/jats:sup>) for 45 days. Animals administered TCDD and those co\u2010administered TCDD and vitamin E did not show any significant change in body weight. Administration of TCDD decreased the weights of the testis, epididymis, seminal vesicles and ventral prostate. The daily sperm production decreased in the animals administered TCDD from the control values of 22.19 \u00b1 2.67 to 13.10 \u00b1 3.16 \u00d7 10<jats:sup>6<\/jats:sup>. There was a significant decline in the activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase with concomitant increased levels of hydrogen peroxide and lipid peroxidation. Co\u2010administration of TCDD and vitamin E did not show any significant changes in the weights of the testis, epididymis, seminal vesicles and ventral prostate. The daily sperm production remained unchanged in the animals co\u2010administered TCDD and vitamin E. The activities of antioxidant enzymes and the levels of hydrogen peroxide and lipid peroxidation did not change in the animals co\u2010administered TCDD and vitamin E. The results suggested that administration of TCDD induces oxidative stress in testis, and vitamin E could impart a protective effect against TCDD\u2010induced oxidative stress. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.866","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T00:43:49Z","timestamp":1034124229000},"page":"345-351","source":"Crossref","is-referenced-by-count":48,"title":["Effects of vitamin E on reactive oxygen species\u2010mediated 2,3,7,8\u2010tetrachlorodi\u2010benzo\u2010<i>p<\/i>\u2010dioxin toxicity in rat testis"],"prefix":"10.1002","volume":"22","author":[{"given":"C.","family":"Latchoumycandane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P.","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8223"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8426"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/096032718900800301"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(98)00017-3"},{"key":"e_1_2_1_6_2","first-page":"403","article-title":"Effect on male fertility and testis concentrations of low dose of 2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin (TCDD) in offspring of rats exposed during pregnancy and lactation","volume":"56","author":"Faqi AS","year":"1997","journal-title":"Teratology"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90052-K"},{"key":"e_1_2_1_8_2","volume-title":"Biological Mechanisms of Dioxin Action","author":"Poland A","year":"1984"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4464"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01055833"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.744"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00221-8"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_2_1_14_2","first-page":"135","article-title":"Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats","volume":"3","author":"Sujatha R","year":"2001","journal-title":"Asian J. Androl."},{"key":"e_1_2_1_15_2","first-page":"205","article-title":"Effect of lindane on antioxidant enzymes in epididymis and epididymal sperm of adult rats","volume":"3","author":"Chitra KC","year":"2001","journal-title":"Asian J. Androl."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00563-7"},{"key":"e_1_2_1_17_2","first-page":"113","article-title":"Induction of oxidative stress in the rat epididymal sperm after exposure to 2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin","volume":"76","author":"Latchoumycandane C","year":"2001","journal-title":"Arch. Toxicol."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1989.tb00091.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00068-7"},{"key":"e_1_2_1_20_2","first-page":"86","article-title":"Application of testicular sperm head counts in the assessment of male reproductive toxicity","volume":"3","author":"Blazak WF","year":"1993","journal-title":"Methods Toxicol."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.951031136"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03714.x"},{"key":"e_1_2_1_23_2","first-page":"283","volume-title":"Handbook of Methods for Oxygen Radical Research","author":"Claiborne A","year":"1985"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41206-4"},{"key":"e_1_2_1_25_2","first-page":"158","article-title":"Studies on quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia DE","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(81)90411-1"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(76)90236-1"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/60.1.132"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(92)90158-B"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(92)90101-W"},{"key":"e_1_2_1_31_2","first-page":"553","volume-title":"Reproductive and Developmental Toxicology","author":"Klinefelter GR","year":"1998"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1982.tb03120.x"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408449009089873"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00301-0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5877-0_115"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6973"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(86)90207-0"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.1997.00044.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.1999.00145.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.5.399"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0810459"},{"key":"e_1_2_1_42_2","first-page":"545","article-title":"Influence of antioxidants on superoxide dismutase activity in bovine sperm","volume":"23","author":"Beconi MT","year":"1991","journal-title":"Biochem. Int."},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(02)00002-3"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.866","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:27:45Z","timestamp":1760552865000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/jat.866"],"URL":"https:\/\/doi.org\/10.1002\/jat.866","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}