{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:40:31Z","timestamp":1760575231050,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,11,6]],"date-time":"2002-11-06T00:00:00Z","timestamp":1036540800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurolathyrism, an upper motor neuron disease, has been thought to be caused by long\u2010term dietary consumption of lathyrus pulse, which contains the toxin \u03b2\u2010<jats:italic>N<\/jats:italic>\u2010oxalyl\u2010<jats:sc>L<\/jats:sc>\u2010\u03b1,\u03b2\u2010diaminopropionic acid. Earlier behavioural studies employing oral feeding of lathyrus pulse to animals has been conducted without evaluating the biochemical toxicity potential. In the present investigation the effect of dietary feeding of 10%, 50% and 80% lathyrus pulse to rats and guinea pigs for 3 months on neurobehavioural parameters, including locomotor activity, inclined plain test and neurotoxicological parameters such as neurotransmitter receptor binding, Ca<jats:sup>2+<\/jats:sup> influx and membrane fluidity, was investigated. Exposure of 50% low and high toxin lathyrus to rats did not cause any significant change in locomotor activity, whereas guinea pigs at the same dosage regimen of high toxin lathyrus showed significant lowering of inclined plain test scores. Furthermore, studies of neuroreceptor binding in rats fed 50% low and high toxin lathyrus showed significant changes in glutamate, dopamine and muscarinic receptors, whereas the benzodiazepine receptor elicited no change. Guinea pigs, on the other hand, fed 50% and 80% lathyrus in the diet showed significant changes in glutamate, dopamine, muscarinic and benzodiazepine receptors. Interestingly, significant elevation in intracellular calcium with a concomitant increase in membrane fluidity was observed in rats (50% low and high toxin) and guinea pigs (50% and 80%) fed a lathyrus diet. These results indicate that although both species (rats and guinea pigs) are susceptible to neurochemical changes on exposure to lathyrus, locomotor changes are only noticed in guinea pigs. Thus, guinea pigs may be more prone to lathyrus toxicity and may serve as a sensitive animal model compared with rats. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.878","type":"journal-article","created":{"date-parts":[[2002,11,8]],"date-time":"2002-11-08T10:24:02Z","timestamp":1036751042000},"page":"415-421","source":"Crossref","is-referenced-by-count":5,"title":["Comparative effect of dietary administration of <i>Lathyrus sativus<\/i> pulse on behaviour, neurotransmitter receptors and membrane permeability in rats and guinea pigs"],"prefix":"10.1002","volume":"22","author":[{"given":"Archana","family":"Amba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Seth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukul","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash K.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K.","family":"Seth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"81","article-title":"An epidemiological study of lathyrism in the district of Rewa, Madhya Pradesh","volume":"52","author":"Dwivedi MP","year":"1964","journal-title":"Ind. J. Med. Res."},{"key":"e_1_2_1_3_2","first-page":"506","article-title":"Inhibitory and excitatory amino acid in cerebrospinal fluid of neurolathyrism patients, a highly prevalent motoneuron disease","volume":"9","author":"Khan JK","year":"1995","journal-title":"Acta Neuron. Scand."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109893"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)(1997)5:1<43::AID-NT7>3.0.CO;2-M"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02532-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/bj1120029","article-title":"The neurotoxin \u03b2\u2010N\u2010oxalyl\u2010\u03b1,\u03b2\u2010diaminopropionic acid, the neurotoxin from the pulse Lathyrus sativus","volume":"112","author":"Cheema PS","year":"1965","journal-title":"Biochem. J."},{"key":"e_1_2_1_8_2","first-page":"880","article-title":"Experimental neurolathyrism in monkeys","volume":"59","author":"Mani KS","year":"1971","journal-title":"Ind. J. Med. Res."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1978.tb10479.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90080-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(79)80002-2"},{"key":"e_1_2_1_12_2","first-page":"124","article-title":"Pathological changes in spinal cord induced by lathyrus neurotoxin (\u03b2\u2010N\u2010oxalylamino\u2010L\u2010alanine) in vitro","volume":"44","author":"Zagoren JC","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"e_1_2_1_13_2","first-page":"348","article-title":"Acute neuronal changes induced in cortex\/cord culture by uncommon plant amino acids","volume":"4","author":"Nunn PB","year":"1986","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90490-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91602-W"},{"key":"e_1_2_1_16_2","first-page":"2577","article-title":"Inhibition of tyrosine amino transferase by \u03b2\u2010N\u2010oxalyl\u2010L\u2010\u03b1,\u03b2\u2010diaminopropionic acid, the Lathyrus sativus neurotoxin","volume":"68","author":"Shashi Vardhan K","year":"1997","journal-title":"J. Neurochem."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-7189(199809\/10)6:5<189::AID-NT22>3.0.CO;2-F"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/249469a0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb11762.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01474681"},{"key":"e_1_2_1_21_2","first-page":"253","article-title":"Effect of chronic oral intake of Lathyrus sativus extract containing \u03b2\u2010N\u2010oxalylamino\u2010L\u2010alanine on 3H\u2010glutamatic binding in different areas of rat brain","volume":"2","author":"La Bella V","year":"1993","journal-title":"Neurodegeneration"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1997.3731"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/60.3.367"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)00958-7"},{"key":"e_1_2_1_25_2","series-title":"Screening Methods in Pharmacology","first-page":"69","author":"Friedman A","year":"1965"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1966.tb09873.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb13008.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90197-6"},{"key":"e_1_2_1_29_2","first-page":"117","article-title":"Platelet derived growth factor blocks the increase in intracellular free Ca2+ caused by calcium ionophores and a volatile anaesthetic agents","volume":"55","author":"Olsen RA","year":"1991","journal-title":"Toxicologist"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(78)90010-2"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement and Folin Phenol reagent","volume":"193","author":"Lowry OH","year":"1951","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_32_2","first-page":"258","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1967"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90112-8"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90109-Z"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/264659a0"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb12899.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(99)00152-7"},{"key":"e_1_2_1_38_2","unstructured":"BangaA.Biochemical basis of lathyrism: Toxicological manifestations and pre\u2010disposing factors. Ph.D dissertation. Lucknow University India2001."},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/211637a0"},{"key":"e_1_2_1_40_2","first-page":"165","article-title":"Lathyrus neurotoxin excitation of nucleus","volume":"20","author":"Krnjevic K","year":"1977","journal-title":"Can. Fed. Biol. Sci."},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231142"},{"key":"e_1_2_1_42_2","first-page":"593","article-title":"Cyclothiazide enhances L\u2010BOAA\u2010, AMPA\u2010, and kainate\u2010evoked calcium and cobalt influx in embryonic rat neural cells","volume":"65","author":"Sonig NK","year":"1995","journal-title":"J. Neurochem. Suppl."},{"key":"e_1_2_1_43_2","first-page":"319","article-title":"Excito amino acid and neurodegeneration","volume":"50","author":"Doble A","year":"1995","journal-title":"Therapie"},{"key":"e_1_2_1_44_2","first-page":"339","volume-title":"Kainic Acid as a Tool in Neurobiology","author":"Olney JW","year":"1978"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90787-0"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00401-7"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.878","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:34:43Z","timestamp":1760528083000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1002\/jat.878"],"URL":"https:\/\/doi.org\/10.1002\/jat.878","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}