{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:32:31Z","timestamp":1768635151631,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T00:00:00Z","timestamp":1041897600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The usefulness of doxorubicin (DXR) is limited by its cardiotoxicity. In order to improve future DXR therapy by using a new antioxidant agent, an experimental study was designed. This study was undertaken to determine whether DXR\u2010induced cardiotoxicity is prevented by erdosteine, a mucolytic agent showing antioxidant properties. Three groups of male Sprague\u2010Dawley rats (60 days old) were used: one group was untreated as a control; the other groups were treated with DXR (single i.p. dosage of 20 mg kg<jats:sup>\u22121<\/jats:sup> body wt.) or DXR plus erdosteine (10 mg kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup>, orally), respectively. The DXR treatment without erdosteine increased antioxidant enzyme activities and also increased lipid peroxidation in myocardial tissue. The rats treated with DXR plus erdosteine produced a significant decrease in lipid peroxidation in comparison with control and DXR groups. Furthermore, erdosteine administration led to an increase in antioxidant enzyme activities in comparison with the control group. Erdosteine treatment also increased the activities of catalase (CAT) and glutathione peroxidase (GSH\u2010Px) in comparison with the DXR group. There was no significant difference in lipid peroxidation of myocardial tissue between control and DXR plus erdosteine\u2010treated rats. It was concluded that erdosteine caused an increase in the activities of antioxidant enzymes, especially GSH\u2010Px and CAT, protecting the heart tissue sufficiently from oxidative damage to membrane lipids and other cellular components induced by DXR. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.889","type":"journal-article","created":{"date-parts":[[2003,1,8]],"date-time":"2003-01-08T16:09:03Z","timestamp":1042042143000},"page":"71-74","source":"Crossref","is-referenced-by-count":78,"title":["Protective effects of erdosteine against doxorubicin\u2010induced cardiomyopathy in rats"],"prefix":"10.1002","volume":"23","author":[{"given":"Ersin","family":"Fadillio\u01e7lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Erdo\u01e7an","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadik","family":"S\u00f6\u01e7\u00fct","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Kuku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00393-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"e_1_2_1_4_1","first-page":"4658","article-title":"Effect of verapamil on doxorubicin cardiotoxicity: altered muscle gene expression in cultured neonatal rat cardiomyocytes","volume":"53","author":"Akimoto H","year":"1993","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00695-5"},{"key":"e_1_2_1_6_1","first-page":"344","article-title":"Effects of erdosteine and its metabolites on bacterial adhesiveness","volume":"49","author":"Braga PC","year":"1999","journal-title":"Drug Res."},{"key":"e_1_2_1_7_1","first-page":"739","article-title":"Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts","volume":"50","author":"Braga PC","year":"2000","journal-title":"Drug Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900355"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652060-00009"},{"key":"e_1_2_1_10_1","first-page":"460","article-title":"Effect of anthracycline antibiotics on oxygen radical formation in rat heart","volume":"43","author":"Doroshow JH","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(93)90307-P"},{"key":"e_1_2_1_12_1","first-page":"407","volume-title":"Methods in Enzymology, vol. 186, Oxygen Radicals in Biological Systems","author":"Esterbauer H","year":"1990"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00419-6"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195713"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000789"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050048"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002400100185"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin\u2010phenol reagent","volume":"183","author":"Lowry O","year":"1951","journal-title":"J. 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