{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:59:11Z","timestamp":1785905951272,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,8]],"date-time":"2004-01-08T00:00:00Z","timestamp":1073520000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Response differences by different strains of mice towards house dust mites (<jats:italic>Dermatophagoides farinae<\/jats:italic>) or diesel exhaust particles (DEP) were investigated. Mouse strains BALB\/c, ICR and C3H\/He received 1 \u00b5g of <jats:italic>D. farinae<\/jats:italic> or 1 \u00b5g of <jats:italic>D. farinae<\/jats:italic> + 50 \u00b5g of DEP intratracheally four times at 2\u2010week intervals. <jats:italic>Dermatophagoides farinae<\/jats:italic> treatment caused the recruitment of eosinophils and lymphocytes. The order of magnitude of the eosinophilic airway in\ufb02ammation was BALB\/c &lt; ICR &lt; C3H\/He mice. The protein levels of eotaxin and IL\u20105 in lung tissues correlated with the manifestations of eosinophilic airway in\ufb02ammation by <jats:italic>D. farinae<\/jats:italic> administration. Diesel exhaust particles aggravated the manifestation of the eosinophilic in\ufb02ammation through goblet cell proliferation in the airway and enhanced the local expression of eotaxin and IL\u20105 in all three strains of mice. The levels of eotaxin and IL\u20105 in lung tissues corresponded to the pathological changes caused by <jats:italic>D. farinae<\/jats:italic> + DEP. The increasing order of production levels of antigen\u2010speci\ufb01c IgG1 by <jats:italic>D. farinae<\/jats:italic> or <jats:italic>D. farinae<\/jats:italic> + DEP was BALB\/c &lt; ICR &lt; C3H\/He mice. The signi\ufb01cant adjuvant effect of DEP on IgG1 production was observed in the C3H\/He mice (<jats:italic>P<\/jats:italic> &lt; 0.05). These results suggest that the murine strain differences in the production of eosinophilic airway in\ufb02ammation by <jats:italic>D. farinae<\/jats:italic> + DEP are related to differences in local expression of IL\u20105 and eotaxin. The enhancing effects of DEP may be mediated by a cytokine increase in the local expression. Antigen\u2010speci\ufb01c IgG1 may be an important immunoglobulin in the pathogenesis of allergic asthma enhanced by DEP. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.949","type":"journal-article","created":{"date-parts":[[2004,1,22]],"date-time":"2004-01-22T03:02:34Z","timestamp":1074740554000},"page":"69-76","source":"Crossref","is-referenced-by-count":25,"title":["Mouse strain differences in eosinophilic airway in\ufb02ammation caused by intratracheal instillation of mite allergen and diesel exhaust particles"],"prefix":"10.1002","volume":"24","author":[{"given":"Takamichi","family":"Ichinose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Sadakane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Sagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shibamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.4049\/jimmunol.150.8.3442","article-title":"RANTES is a chemotactic and activating factor for human eosinophils","volume":"150","author":"Alam R","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111141"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12020432"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.3.7873190"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00520.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000024157"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70233-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4921"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.111144"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.107-1566224"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.195"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90151-S"},{"key":"e_1_2_1_14_1","first-page":"382","article-title":"Glucocorticoids inhibit granulocyte\u2010macrophage colony\u2010stimulating factor\u20101 and interleukin\u20105 enhanced in vitro survival of human eosinophils","volume":"75","author":"Hallsworth MP","year":"1992","journal-title":"Immunology"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111146"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(97)00096-6"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/44.1.70"},{"key":"e_1_2_1_18_1","volume-title":"Report on School Health Survey","author":"Japan Ministry of Education, Science and Culture (JMESC)","year":"2000"},{"key":"e_1_2_1_19_1","first-page":"270","article-title":"Nasal allergy and air pollution","volume":"23","author":"Kaneko S","year":"1980","journal-title":"Otorhinolaryngol. Tokyo"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117986"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.5.885"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1344"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70021-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11020291"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053781"},{"key":"e_1_2_1_26_1","first-page":"192","article-title":"A study on the prevalence of bronchial asthma in school children in western districts of Japan \u2014 comparison between the studies in 1982 and in 1992 with the same methods and same districts","volume":"42","author":"Nishima S","year":"1993","journal-title":"Arerugi"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/370367a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.3_Pt_1.668"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.3_Pt_1.669"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90118-Y"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756798"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.4.785"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064255"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70024-2"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.4.826"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62490-8"},{"key":"e_1_2_1_37_1","first-page":"187","article-title":"Adjuvant activity of diesel exhaust particulates (DEP) in production of anti\u2010IgE and anti\u2010Ig1 antibodies to mite allergen in mice","volume":"48","author":"Suzuki T","year":"1996","journal-title":"J. Clin. Lab. Immunol."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.11.3796"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(87)80161-6"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.9610054"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8437"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:21:33Z","timestamp":1760523693000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/jat.949"],"URL":"https:\/\/doi.org\/10.1002\/jat.949","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}