{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:53:39Z","timestamp":1773327219890,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T00:00:00Z","timestamp":1203552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used advanced spectral imaging for intrasurgical decision making in a preclinical study, on a mouse model of Hirschsprung's Disease. Our imaging device sampled areas from normal and abnormal (aganglionic) colon in these animals. Spectral segmentation and classification of the resulting images showed a clear distinction between the normal and aganglionic regions, as confirmed by pathological analysis and use of mutant mice. We developed a simple algorithm that could distinguish normal from aganglionic colon with high spatial resolution and reproducibility, and the following statistics: sensitivity = 97%, specificity = 94%, positive predictive value = 92%, negative predictive value = 98%. These studies showed translational proof of concept that spectral imaging could be used during operations, in real time, to help surgeons precisely distinguish normal from abnormal tissue without requiring traditional biopsy. (\u00a9 2008 WILEY\u2010VCH Verlag GmbH &amp; Co. KGaA, Weinheim)<\/jats:p>","DOI":"10.1002\/jbio.200710016","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T14:47:53Z","timestamp":1203605273000},"page":"97-103","source":"Crossref","is-referenced-by-count":19,"title":["Spectral imaging for precise surgical intervention in Hirschsprung's Disease"],"prefix":"10.1002","volume":"1","author":[{"given":"Philip K.","family":"Frykman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik H.","family":"Lindsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gaon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1103-1269"},{"key":"e_1_2_1_3_2","unstructured":"K.Burton J.Jeong S.Wachsmann\u2010Hogiu andD. 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W.Vannier \u201cInfrastructure for Image Guided Surgery\u201d at http:\/\/www.radiology.uiowa.edu\/NEWS\/Haller\u2010PDF.pdf."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90017-5"},{"key":"e_1_2_1_12_2","first-page":"36","article-title":"Newborn endothelin receptor type B mutant (piebald) mice have a higher resting anal sphincter pressure than newborn C57BL\/6 mice","volume":"42","author":"Nadler E. P.","year":"2003","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"key":"e_1_2_1_13_2","unstructured":"P. K.Frykman M.Gaon E.Lindsley J.Lechago A. P.Chung Y.Xiong andD.L Farkas A Novel Rapid and Accurate Method for Determining the Level of Aganglionosis in Hirschsprung's Disease Using Spectral Bioimaging Proc. IPEG (2006) Presentation Abstract p. 76."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.200882"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","unstructured":"D. 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