{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:17:45Z","timestamp":1789449465646,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The techniques of medical imaging allow the detection of suspect lesions in the breast, but they do not always evidence the malignant nature of these lesions. Breast biopsies and histological analyses are therefore implemented to establish a diagnosis. In order to reduce the number of these invasive procedures, a portable clinical system was designed based upon the excitation of Endogenous Fluorescence\n                    <jats:italic>in vivo<\/jats:italic>\n                    at 405 nm via a fiber\u2010optics probe included in a disposable needle of small diameter (&lt;1 mm). From the fluorescence signal, the authors are able to discriminate between diseased and healthy areas of human breast biopsies. Stronger fluorescence intensity and systematic spectral red shift of the tumor areas were observed. These results are confirmed by confocal microscopy. This new instrument is promising for the minimally invasive diagnosis of breast tumors\n                    <jats:italic>in vivo<\/jats:italic>\n                    with an appreciable limitation of patient trauma and of operational and financial cost. (\u00a9 2010 WILEY\u2010VCH Verlag GmbH &amp; Co. KGaA, Weinheim)\n                  <\/jats:p>","DOI":"10.1002\/jbio.200900070","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T10:19:56Z","timestamp":1259662796000},"page":"373-384","source":"Crossref","is-referenced-by-count":23,"title":["Towards an optical biopsy for the diagnosis of breast cancer\n                    <i>in vivo<\/i>\n                    by endogenous fluorescence spectroscopy"],"prefix":"10.1002","volume":"3","author":[{"given":"Lama","family":"Alchab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Balleyguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Pierre","family":"Fontaine\u2010Aupart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Farcy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,18]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"J. 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