{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:09:42Z","timestamp":1791918582125,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T00:00:00Z","timestamp":1334275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The investigation of lung dynamics on alveolar scale is crucial for the understanding and treatment of lung diseases, such as acute lung injury and ventilator induced lung injury, and to promote the development of protective ventilation strategies. One approach to this is the establishment of numerical simulations of lung tissue mechanics where detailed knowledge about three\u2010dimensional alveolar structure changes during the ventilation cycle is required. We suggest four\u2010dimensional optical coherence tomography (OCT) imaging as a promising modality for visualizing the structural dynamics of single alveoli in subpleural lung tissue with high temporal resolution using a mouse model. A high\u2010speed OCT setup based on Fourier domain mode locked laser technology facilitated the acquisition of alveolar structures without noticeable motion artifacts at a rate of 17 three\u2010dimensional stacks per ventilation cycle. The four\u2010dimensional information, acquired in one single ventilation cycle, allowed calculating the volume\u2010pressure curve and the alveolar compliance for single alveoli. (\u00a9 2013 WILEY\u2010VCH Verlag GmbH &amp; Co. KGaA, Weinheim)<\/jats:p>","DOI":"10.1002\/jbio.201200027","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T07:37:28Z","timestamp":1334302648000},"page":"148-152","source":"Crossref","is-referenced-by-count":15,"title":["Four\u2010dimensional imaging of murine subpleural alveoli using high\u2010speed optical coherence tomography"],"prefix":"10.1002","volume":"6","author":[{"given":"Lars","family":"Kirsten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gaertner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schnabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.1378"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3247149"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3425654"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957169"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1364\/OE.18.014685"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00348.2007"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.889615"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.889463"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3275472"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.3.1060"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003950070029"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201200027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201200027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:53:41Z","timestamp":1700628821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201200027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,13]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/jbio.201200027"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201200027","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,13]]}}}