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In this paper we have investigated the short\u2010 and long\u2010term biodistribution of intact fluorescent CdSe\/CdS\/ZnS QD coated by 3\u2010mercaptopropionic acid in mice. The results showed that intravenously injected QD accumulated mainly in the lungs, liver and spleen and were retained in these tissues for over 22 days. QD caused signs of acute toxicity in mice including death. The investigated QD possibly caused vascular thrombosis. The results of a toxicological assay indicated that some histopathological changes occurred in the lung tissue after the injection of QD. Our study highlights the need for careful evaluation of QD safety before their use in biological applications. (\u00a9 2012 WILEY\u2010VCH Verlag GmbH &amp; Co. 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