{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:10:01Z","timestamp":1700698201070},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary Hemorrhagic Telangiectasia\u20101 (HHT\u20101) is a vascular disease caused by mutations in the endoglin (Eng)\/CD105 gene. The objective of this study was to quantify the oxidative state of a rodent model of HHT\u20101 using an optical imaging technique. We used a cryofluorescence imaging instrument to quantitatively assess tissue metabolism in this model. Mitochondrial redox ratio (FAD\/NADH), FAD RR, was used as a quantitative marker of the metabolic status and was examined in the kidneys, and eyes of wild\u2010type and Eng +\/\u2013 mice. Kidneys and eyes from wild\u2010type P21, 6W, and 10M old mice showed, respectively, a 9% (\u00b12), 24% (\u00b10.4), 15% (\u00b11), and 23% (\u00b14), 33% (\u00b10.6), and 30% (\u00b12) change in the mean FAD RR compared to Eng +\/\u2013 mice at the same age. Thus, endoglin haploinsufficiency is associated with less oxidative stress in various organs and mitigation of angiogenesis. (\u00a9 2014 WILEY\u2010VCH Verlag GmbH &amp; Co. 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