{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:04:47Z","timestamp":1783181087323,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Fibrillar forms of the Amyloid\u2010\u03b2 (A\u03b2) protein have been implicated in the early stages of Alzheimer's disease (AD), however there are no standardised assays for soluble A\u03b2 oligomer biomarkers that provide the best indication of the disease progression [1,2]. As a step towards a fast and label\u2010free method for testing different AD biomarkers, we have combined laser nano\u2010textured substrates with a SERS mapping technique and validated it using soluble A\u03b2\u201040 oligomers [3\u20105]. The nano\u2010textured SERS substrates provide fast (&amp;5\u00a0min), label\u2010free spectra associated with soluble A\u03b2\u201040 oligomers down to a concentration of 10 nM. Statistical analysis of the spectral intensities mapped over the substrate surface shows a quantitative correlation with the oligomer concentration.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>Schematics of experiments: SERS mapping of A\u03b2\u201040 (left figure: measured SERS intensity overlayed with an SEM image of ripples) was carried out on the laser nano\u2010textured (ripple) surface of sapphire and statistical analysis of the SERS intensity was carried out for qualitative (a high SERS intensity at low probability) and quantitative (a moderate SERS intenisty at the highest probability) measures. Quantitative statistical analysis of SERS mapping data can be performed off line for cross correlations with other known SERS signatures.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201400017-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>Schematics of experiments: SERS mapping of A\u03b2\u201040 (left figure: measured SERS intensity overlayed with an SEM image of ripples) was carried out on the laser nano\u2010textured (ripple) surface of sapphire and statistical analysis of the SERS intensity was carried out for qualitative (a high SERS intensity at low probability) and quantitative (a moderate SERS intenisty at the highest probability) measures. Quantitative statistical analysis of SERS mapping data can be performed off line for cross correlations with other known SERS signatures.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201400017","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T20:36:20Z","timestamp":1407962180000},"page":"567-574","source":"Crossref","is-referenced-by-count":44,"title":["Statistically quantified measurement of an Alzheimer's marker by surface\u2010enhanced Raman scattering"],"prefix":"10.1002","volume":"8","author":[{"given":"Ri\u010dardas","family":"Buividas","sequence":"first","affiliation":[{"name":"Centre for Micro\u2010Photonics and The Australian National Fabrication Facility \u2013 ANFF Faculty of Science, Engineering and Technology, Swinburne University of Technology  Hawthorn VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerijus","family":"Dzingelevi\u010dius","sequence":"additional","affiliation":[{"name":"Centre for Micro\u2010Photonics and The Australian National Fabrication Facility \u2013 ANFF Faculty of Science, Engineering and Technology, Swinburne University of Technology  Hawthorn VIC 3122 Australia"},{"name":"Department of Bioelectrochemistry and Biospectroscopy Vilnius University Institute of Biochemistry  Mokslinink\u0173 12 LT\u201008662 Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Kubili\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Centre for Micro\u2010Photonics and The Australian National Fabrication Facility \u2013 ANFF Faculty of Science, Engineering and Technology, Swinburne University of Technology  Hawthorn VIC 3122 Australia"},{"name":"Laboratory of Biomedical Physics Vilnius University Institute of Oncology  Baublio 3A Vilnius LT\u201008406 Lithuania"},{"name":"Research Centre for Microsystems and Nanotechnology Kaunas University of Technology  Studentu 65 LT\u201051369 Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Stoddart","sequence":"additional","affiliation":[{"name":"Faculty of Science, Engineering and Technology Swinburne University of Technology  Hawthorn VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi","family":"Khanh Truong","sequence":"additional","affiliation":[{"name":"Faculty of Science, Engineering and Technology Swinburne University of Technology  Hawthorn VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena P.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Faculty of Science, Engineering and Technology Swinburne University of Technology  Hawthorn VIC 3122 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulius","family":"Juodkazis","sequence":"additional","affiliation":[{"name":"Centre for Micro\u2010Photonics and The Australian National Fabrication Facility \u2013 ANFF Faculty of Science, Engineering and Technology, Swinburne University of Technology  Hawthorn VIC 3122 Australia"},{"name":"Melbourne Centre for Nanofabrication Australian National Fabrication Facility  Clayton VIC 3168 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"e_1_2_6_1_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3842"},{"key":"e_1_2_6_1_1_3_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrd3842-c1","volume":"12","author":"Aisen P. 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