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We analyzed data from 20 AD patients, 18 patients with other neurodegenerative dementias (OD) and 10 healthy control (HC) subjects. NIR Raman microspectroscopy differentiated patients with more than 95% sensitivity and specificity. We demonstrated the high discriminative power of artificial neural network (ANN) classification models, thus revealing the high potential of this developed methodology for the differential diagnosis of AD. Raman spectroscopic, blood\u2010based tests may aid clinical assessments for the effective and accurate differential diagnosis of AD, decrease the labor, time and cost of diagnosis, and be useful for screening patient populations for AD development and progression.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>Multivariate data analysis of blood serum Raman spectra allows for the differentiation between patients with Alzheimer's disease, other types of dementia and healthy individuals.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201400060-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>Multivariate data analysis of blood serum Raman spectra allows for the differentiation between patients with Alzheimer's disease, other types of dementia and healthy individuals.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201400060","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T19:05:32Z","timestamp":1411671932000},"page":"584-596","source":"Crossref","is-referenced-by-count":132,"title":["Raman spectroscopy of blood serum for Alzheimer's disease diagnostics: specificity relative to other types of dementia"],"prefix":"10.1002","volume":"8","author":[{"given":"Elena","family":"Ryzhikova","sequence":"first","affiliation":[{"name":"Department of Chemistry University at Albany, SUNY 1400 Washington Avenue Albany NY 12222 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Kazakov","sequence":"additional","affiliation":[{"name":"Department of Physics University at Albany, SUNY 1400 Washington Avenue Albany NY 12222 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Halamkova","sequence":"additional","affiliation":[{"name":"Department of Chemistry University at Albany, SUNY 1400 Washington Avenue Albany NY 12222 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzintra","family":"Celmins","sequence":"additional","affiliation":[{"name":"Alzheimer's Center and Movement Disorders Program Department of Neurology of Albany Medical Center Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Malone","sequence":"additional","affiliation":[{"name":"Alzheimer's Center and Movement Disorders Program Department of Neurology of Albany Medical Center Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Molho","sequence":"additional","affiliation":[{"name":"Parkinson's Disease and Movement Disorders Center of Albany Medical Center Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl A.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Alzheimer's Center and Movement Disorders Program Department of Neurology of Albany Medical Center Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor K.","family":"Lednev","sequence":"additional","affiliation":[{"name":"Department of Chemistry University at Albany, SUNY 1400 Washington Avenue Albany NY 12222 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.11.007"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.02.001"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.6.9.1293"},{"issue":"2","key":"e_1_2_6_1_6_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1093\/ajhp\/55.suppl_2.S5","volume":"55","author":"Farlow M. 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