{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:21:42Z","timestamp":1772767302354,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Despite initially positive responses, recurrences after Photodynamic treatment (PDT) can occur and there is need for improvement in the effectiveness of PDT. Our study uniquely showed that there was a significantly gap junctional intercellular communication (GJIC)\u2010dependent PDT cytotoxicity. The presence of GJIC composed of Connexin 32 increased the PDT phototoxicity in transfected HeLa cells and in the xenograft tumors, and the enhanced phototoxicity of Photofrin\u2010mediated PDT by GJIC was related with ROS and calcium pathways. Our study indicates the possibility that up\u2010regulation or maintenance of gap junction functionality may be used to increase the efficacy of PDT.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>The phototoxicity effect of Photofrin was substantially greater in Dox\u2010treated cells, which expressed the Cx32 and formed the GJ, than Dox\u2010untreated.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201400131-gra-001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>The phototoxicity effect of Photofrin was substantially greater in Dox\u2010treated cells, which expressed the Cx32 and formed the GJ, than Dox\u2010untreated.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201400131","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T13:18:43Z","timestamp":1421673523000},"page":"764-774","source":"Crossref","is-referenced-by-count":15,"title":["GJIC Enhances the phototoxicity of photofrin\u2010mediated photodynamic treatment by the mechanisms related with ROS and Calcium pathways"],"prefix":"10.1002","volume":"8","author":[{"given":"Dengpan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacology Pharmacy School of Xuzhou Medical College  221004 Xuzhou P.R. China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Pharmacy School of Xuzhou Medical College  221004 Xuzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine Sun Yat\u2010Sen University  74 Zhongshan 2nd Road Guangzhou 510080 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengfang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics the Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 510080 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine Sun Yat\u2010Sen University  74 Zhongshan 2nd Road Guangzhou 510080 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine Sun Yat\u2010Sen University  74 Zhongshan 2nd Road Guangzhou 510080 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; Systems Biology University of Toronto  Ontario M5S3G5 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine Sun Yat\u2010Sen University  74 Zhongshan 2nd Road Guangzhou 510080 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine Sun Yat\u2010Sen University  74 Zhongshan 2nd Road Guangzhou 510080 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2009.11.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20363"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.01.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.11.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.011417098"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0811"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03343"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21068"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3022516"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.103.035097"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.083428"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040806"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.179"},{"key":"e_1_2_6_15_1","first-page":"490","volume":"18","author":"Goldberg G. S.","year":"1995","journal-title":"Biotechniques"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.11.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2002)0750140IVAIVE2.0.CO2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900090308"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.07.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.10071"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205881"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199906)34:6<661::AID-JMS818>3.0.CO;2-I"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb04816.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00386-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1140"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.09.017"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0432-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.4.C1291"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0281OC"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01093.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/2210"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206961"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.12.022"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2089"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12021041"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.11.048"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(93)81242-6"},{"key":"e_1_2_6_38_1","first-page":"774","volume":"740","author":"Orellana J. A.","year":"2012","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.1.282"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.01.042"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80570-3"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201400131","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201400131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:26:53Z","timestamp":1696390013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201400131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,19]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/jbio.201400131"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201400131","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,19]]}}}