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We demonstrate the first site\u2010matched application of Brillouin microscopy, Raman microscopy and FTIR micro\u2010spectroscopic imaging to <jats:italic>ex\u2010vivo<\/jats:italic> epithelial tissue \u2013 Barrett's oesophagus. The mechanical and chemical characters of the epithelium were assessed in histological sections from a patient subjected to endoscopic oesophageal biopsy. Previous studies have shown that both these properties change within the oesophageal wall, owing to the presence of distinct cellular and extracellular constituents which are putatively affected by oesophageal cancer. Brillouin microscopy enables maps of elasticity of the epithelium to be obtained, whilst Raman and FTIR imaging provide \u2019chemical images' without the need for labelling or staining. This site\u2010matched approach provides a valuable platform for investigating the structure, biomechanics and composition of complex heterogeneous systems. A combined Brillouin\u2010Raman device has potential for <jats:italic>in\u2010vivo<\/jats:italic> diagnosis of pathology.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>First application of site\u2010matched micro Brillouin, Raman and FTIR spectroscopic imaging to epithelial tissue in Barrett's oesophagus<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201600038-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>First application of site\u2010matched micro Brillouin, Raman and FTIR spectroscopic imaging to epithelial tissue in Barrett's oesophagus<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201600038","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T16:55:42Z","timestamp":1460998542000},"page":"694-700","source":"Crossref","is-referenced-by-count":32,"title":["Chemico\u2010mechanical imaging of Barrett's oesophagus"],"prefix":"10.1002","volume":"9","author":[{"given":"Francesca","family":"Palombo","sequence":"first","affiliation":[{"name":"University of Exeter School of Physics  Exeter EX4 4QL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Madami","sequence":"additional","affiliation":[{"name":"University of Perugia Department of Physics and Geology  Perugia I\u201006100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Fioretto","sequence":"additional","affiliation":[{"name":"University of Perugia Department of Physics and Geology  Perugia I\u201006100 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