{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:34:42Z","timestamp":1780518882407,"version":"3.54.1"},"reference-count":60,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FAPESP (State of S\u00e3o Paulo Research Foundation)","award":["#2014\/21214-1"],"award-info":[{"award-number":["#2014\/21214-1"]}]},{"name":"FAPESP (State of S\u00e3o Paulo Research Foundation)","award":["#2014\/16752-4"],"award-info":[{"award-number":["#2014\/16752-4"]}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["PDSE-18807\/12-7"],"award-info":[{"award-number":["PDSE-18807\/12-7"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Low\u2010power laser irradiation (LPLI) has been extensively employed to modulate inflammation <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Previous reports from our group indicated that LPLI might regulate glycemia in diabetic animals. Diabetes results in chronic hyperglycemia and therefore chronic inflammation by upregulation of inflammatory markers such as the high mobility group box 1 (HMGB1) protein. Thus this study aimed to analyze the LPLI effects upon blood glucose levels, plasma insulin and HMGB1 concentrations in a diabetes experimental rat model. Streptozotocin\u2010induced diabetic rats were irradiated in the salivary glands area with a diode laser applied at 660\u00a0nm, 70\u00a0mW, 20\u00a0J\/cm<jats:sup>2<\/jats:sup>, 22.4\u00a0J, with a spot area of 0.028\u00a0cm<jats:sup>2<\/jats:sup> and its effects were evaluated. LPLI significantly reduced diabetic rat hyperglycemia, without changing insulin or HMGB1 plasma levels, but possibly by ameliorating the insulin resistance in these animals. These findings suggest that LPLI might have a systemic effect, but more studies are necessary to better understand its mechanisms.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>Fasting blood glucose measured by peroxidase\u2010glucose oxidase (PGO) method (<jats:bold>A<\/jats:bold>), showing a reduction of diabetic animals glycemia after LPLI. LPLI probably reduced the hyperglycemia in diabetes by improving the insulin resistance in these animals (<jats:bold>B<\/jats:bold>). C <jats:italic>n<\/jats:italic>\u00a0=\u00a010, CL <jats:italic>n<\/jats:italic>\u00a0=\u00a010, D <jats:italic>n<\/jats:italic>\u00a0=\u00a07 and DL <jats:italic>n<\/jats:italic>\u00a0=\u00a08. Data are expressed as mean \u00b1 SD; * <jats:italic>P<\/jats:italic> &lt;\u00a00.05 vs. respective control group; # <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 vs. D group.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201600175-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>Fasting blood glucose measured by peroxidase\u2010glucose oxidase (PGO) method (<jats:bold>A<\/jats:bold>), showing a reduction of diabetic animals glycemia after LPLI. LPLI probably reduced the hyperglycemia in diabetes by improving the insulin resistance in these animals (<jats:bold>B<\/jats:bold>). C <jats:italic>n<\/jats:italic>\u00a0=\u00a010, CL <jats:italic>n<\/jats:italic>\u00a0=\u00a010, D <jats:italic>n<\/jats:italic>\u00a0=\u00a07 and DL <jats:italic>n<\/jats:italic>\u00a0=\u00a08. Data are expressed as mean \u00b1 SD; * <jats:italic>P<\/jats:italic> &lt;\u00a00.05 vs. respective control group; # <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 vs. D group.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201600175","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T04:31:46Z","timestamp":1476333106000},"page":"1246-1254","source":"Crossref","is-referenced-by-count":12,"title":["Low\u2010power laser irradiation in salivary glands reduces glycemia in streptozotocin\u2010induced diabetic female rats"],"prefix":"10.1002","volume":"9","author":[{"given":"C\u00edntia Yuki","family":"Fukuoka","sequence":"first","affiliation":[{"name":"Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo 05508\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Torres Schr\u00f6ter","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo 05508\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo 05508\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyne","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo 05508\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Dept. of Noncommunicable Disease Surveillance Definition diagnosis and classification of diabetes mellitus and its complications : report of a WHO consultation. 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