{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T22:14:39Z","timestamp":1713305679964},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473697"],"award-info":[{"award-number":["81473697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Osteonecrosis of the femoral head (ONFH), a recalcitrant and disabling disease, is caused by inadequate or fully disrupted blood supply to the affected segment of the subchondral bone. Theoretically, there will develop gas\u2010filled pores during the bone decay process due to lacking blood supply. Unfortunately, the relationship between the gas\u2010filled pores and ONFH is still unclear. Here, we have introduced diode laser absorption spectroscopy to detect oxygen and water vapor signals in the femoral heads from hip replacement in 19 patients. Five samples are affected by osteoarthritis (OA) and the others are related to ONFH. Oxygen and water vapor signals could be obtained, demonstrating the presence of gas\u2010filled pores in both the OA and ONFH groups while the measurement results showed no significant difference. A study of gas exchange was also performed on one excised bone sample to study how these gas pores communicate with the ambient air. The results suggested that the obtained oxygen signals inside the bone samples originate from the invasion of ambient air, which is not expected <jats:italic>in vivo<\/jats:italic>. In conclusion, the ability to detect the gas signal of laser absorption spectroscopy shows the potential for the medical application of assessing the human femoral head <jats:italic>in vivo<\/jats:italic>.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201600229-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201600229","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T00:51:18Z","timestamp":1482627078000},"page":"1356-1364","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostics of femoral head status in humans using laser spectroscopy \u2013 <i>In vitro<\/i> studies"],"prefix":"10.1002","volume":"10","author":[{"given":"Huiying","family":"Lin","sequence":"first","affiliation":[{"name":"Center for Optical and Electromagnetic Research South China Normal University  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wansha","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Optical and Electromagnetic Research South China Normal University  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Optical and Electromagnetic Research South China Normal University  Guangzhou 510006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Orthopedics Department, First Affiliated Hospital Guangzhou University of Chinese Medicine, State Key Orthopedic Laboratory of Chinese Medicine  16, Jichang Road, Baiyun Area Guangzhou 510405 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delong","family":"Chen","sequence":"additional","affiliation":[{"name":"First Clinical Medicine School of Chinese Medicine Guangzhou University of Chinese Medicine  12, Jichang Road, Baiyun Area Guangzhou 510405 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Orthopedics Department, First Affiliated Hospital Guangzhou University of Chinese Medicine, State Key Orthopedic Laboratory of Chinese Medicine  16, Jichang Road, Baiyun Area Guangzhou 510405 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sune","family":"Svanberg","sequence":"additional","affiliation":[{"name":"Center for Optical and Electromagnetic Research South China Normal University  Guangzhou 510006 China"},{"name":"Lund Laser Center Lund University  SE\u2010221 00 Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Svanberg","sequence":"additional","affiliation":[{"name":"Center for Optical and Electromagnetic Research South China Normal University  Guangzhou 510006 China"},{"name":"Lund Laser Center Lund University  SE\u2010221 00 Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.04.002"},{"key":"e_1_2_6_3_1","volume-title":"A Textbook of X\u2010ray Diagnosis: By British Authors","author":"Shanks S. 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