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The proposed approach is tested by imaging mouse ear pinna <jats:italic>in vivo<\/jats:italic>, demonstrating its capability of providing detailed microvascular networks with high contrast, and high temporal and spatial resolutions. It is expected to provide further opportunities for laser speckle imaging in the biomedical and clinical applications where microvascular response to certain stimulus or tissue injury is of interest.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201600237-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201600237","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T08:56:42Z","timestamp":1480409802000},"page":"805-810","source":"Crossref","is-referenced-by-count":11,"title":["Dynamic laser speckle angiography achieved by eigen\u2010decomposition filtering"],"prefix":"10.1002","volume":"10","author":[{"given":"Chenxi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Washington  3720 15th Ave NE Seattle WA 98195 USA"},{"name":"College of Precision Instrument and Optoelectronics Engineering Tianjin University  92 Weijin Road Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Washington  3720 15th Ave NE Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4018(81)90428-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3285504"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.60734"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.6.066018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.25.000009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.44.001823"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.16.001975"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.003211"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.31.001824"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.31.003465"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.8.086009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781410600455"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25240"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2428634"},{"key":"e_1_2_6_16_1","volume-title":"Clive Barker's books of blood","author":"Barker C.","year":"1984"},{"key":"e_1_2_6_17_1","volume-title":"Mathematical Methods and Algorithms for Signal Processing","author":"Moon T. 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