{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:02:48Z","timestamp":1768338168665,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["16H04273"],"award-info":[{"award-number":["16H04273"]}]},{"name":"JSPS KAKENHI","award":["26293425"],"award-info":[{"award-number":["26293425"]}]},{"name":"JSPS KAKENHI","award":["16\u2005K15816, 26242051 and 24650286"],"award-info":[{"award-number":["16\u2005K15816, 26242051 and 24650286"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumor metastasis to lymph nodes is an important contributory factor for cancer\u2010related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX\u2010TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma\u2010like cells) and intranodal DOX release was activated using near\u2010infrared (NIR) laser irradiation. The temperature changes arising from the laser\u2010irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co\u2010therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR\u2010activated hyperthermia. <jats:italic>In vivo<\/jats:italic> bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis.<\/jats:p>","DOI":"10.1002\/jbio.201600241","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T07:06:43Z","timestamp":1492499203000},"page":"1676-1682","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of tumor in lymph nodes using near\u2010infrared laser light\u2010activated thermosensitive liposome\u2010encapsulated doxorubicin and gold nanorods"],"prefix":"10.1002","volume":"10","author":[{"given":"Daisuke","family":"Matsuki","sequence":"first","affiliation":[{"name":"Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"},{"name":"Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oladipo","family":"Adewale","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry University of Johannesburg  Doornfontein Campus P.O. Box 17011 Doornfontein 2028 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Horie","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"},{"name":"Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnosuke","family":"Okajima","sequence":"additional","affiliation":[{"name":"Institute of Fluid Science Tohoku University  2-1-1 Katahira, Aoba Sendai 980-8577 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuki","family":"Komiya","sequence":"additional","affiliation":[{"name":"Institute of Fluid Science Tohoku University  2-1-1 Katahira, Aoba Sendai 980-8577 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwatobi","family":"Oluwafemi","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry University of Johannesburg  Doornfontein Campus P.O. Box 17011 Doornfontein 2028 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenao","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Institute of Fluid Science Tohoku University  2-1-1 Katahira, Aoba Sendai 980-8577 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"},{"name":"Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"},{"name":"Department of Oral and Maxillofacial Surgery Tohoku University Hospital  1-1 Seiryo, Aoba Sendai 980-8575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kodama","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"},{"name":"Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering Tohoku University  4-1 Seiryo, Aoba Sendai 980-8575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.07.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar2003122"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.07.062"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.08.019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.10.045"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.073"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.03.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.10.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-015-0884-x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.10731"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-011-9383-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.043"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.06.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm900185u"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000162"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201104714"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja412735p"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.05.094"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(86)90105-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.01.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","unstructured":"L. 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