{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:09:23Z","timestamp":1790795363765,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science, ICT and future Planning","award":["NRF-2013R1A2A2A03067417"],"award-info":[{"award-number":["NRF-2013R1A2A2A03067417"]}]},{"name":"Ministry of Science, ICT and future Planning","award":["NRF-2016R1A2B2007862"],"award-info":[{"award-number":["NRF-2016R1A2B2007862"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>\n                    Use of photostimulation including low\u2010level light emitting diode (LED) therapy has broadened greatly in recent years because it is compact, portable, and easy to use. Here, the effects of photostimulation by LED (610\u00a0nm) therapy on ischemic brain damage was investigated in mice in which treatment started after a stroke in a clinically relevant setting. The mice underwent LED therapy (20\u00a0min) twice a day for 3 days, commencing at 4 hours post\u2010ischemia. LED therapy group generated a significantly smaller infarct size and improvements in neurological function based on neurologic test score. LED therapy profoundly reduced neuroinflammatory responses including neutrophil infiltration and microglia activation in the ischemic cortex. LED therapy also decreased cell death and attenuated the NLRP3 inflammasome, in accordance with down\u2010regulation of pro\u2010inflammatory cytokines IL\u20101\u03b2 and IL\u201018 in the ischemic brain. Moreover, the mice with post\u2010ischemic LED therapy showed suppressed TLR\u20102 levels, MAPK signaling and NF\u2010kB activation. These findings suggest that by suppressing the inflammasome, LED therapy can attenuate neuroinflammatory responses and tissue damage following ischemic stroke. Therapeutic interventions targeting the inflammasome via photostimulation with LED may be a novel approach to ameliorate brain injury following ischemic stroke.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:caption>\n                        <jats:p>Effect of post\u2010ischemic low\u2010level light emitting diode therapy (LED\u2010T) on infarct reduction was mediated by inflammasome suppression.<\/jats:p>\n                      <\/jats:caption>\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201600244-gra-0001-m.png\">\n                        <jats:alt-text>magnified image<\/jats:alt-text>\n                        <jats:caption>\n                          <jats:p>Effect of post\u2010ischemic low\u2010level light emitting diode therapy (LED\u2010T) on infarct reduction was mediated by inflammasome suppression.<\/jats:p>\n                        <\/jats:caption>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/jbio.201600244","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T03:07:06Z","timestamp":1486350426000},"page":"1502-1513","source":"Crossref","is-referenced-by-count":55,"title":["Low\u2010level light emitting diode (LED) therapy suppresses inflammasome\u2010mediated brain damage in experimental ischemic stroke"],"prefix":"10.1002","volume":"10","author":[{"given":"Hae In","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, School of Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Korean Medical Science Research Center for Healthy\u2010Aging Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"},{"name":"Department of Korean Medical Science, School of Korean Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Center of Color Seven  Seoul 137\u2010867 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung\u2010Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Medical Research Center of Color Seven  Seoul 137\u2010867 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Tae","family":"Choi","sequence":"additional","affiliation":[{"name":"Korean Medical Science Research Center for Healthy\u2010Aging Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"},{"name":"Department of Korean Medical Science, School of Korean Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"},{"name":"Division of Meridian and Structural Medicine, School of Korean Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, School of Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital  Yangsan Gyeongnam 626\u2010770 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa Kyoung","family":"Shin","sequence":"additional","affiliation":[{"name":"Korean Medical Science Research Center for Healthy\u2010Aging Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"},{"name":"Department of Korean Medical Science, School of Korean Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"},{"name":"Division of Meridian and Structural Medicine, School of Korean Medicine Pusan National University  Yangsan Gyeongnam 626\u2010870 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.11.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2005.12.028"},{"key":"e_1_2_9_5_1","first-page":"188","volume":"144","author":"Garcia J. H.","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.143"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65167"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00288"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.326"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.09.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01046.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.4.1365"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10759"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.04.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-5-46"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2814"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2012.3261"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120817"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-40"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.06.012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2002)0760164BEOPL2.0.CO2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0454-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201200077"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.147"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335547"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1745"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-219"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.01.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16959"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.08.077"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.09.001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09513"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3233"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3452"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301681"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.03.001"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.07.014"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.14-032.Agrawal"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-150559"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1981.tb09063.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047460"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132715"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.242"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199910000-00006"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2534856100"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90490-5"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.04.017"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.3.613"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401087"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.534503"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2953"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2459-07.2007"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1691"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01661-1"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-18-07046.2001"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1124425"},{"key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-2010-100894","volume":"23","author":"Taboada L.","year":"2011","journal-title":"Journal of Alzheimer's disease: JAD"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201600244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201600244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:15:00Z","timestamp":1694520900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201600244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/jbio.201600244"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201600244","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}