{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:23:39Z","timestamp":1789820619743,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81402946"],"award-info":[{"award-number":["No. 81402946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In spite of the promising initial treatment responses presented by photodynamic therapy (PDT), 5\u2010year recurrence rates remain high level. Therefore, improvement in the efficacy of PDT is needed. There are reports showing that connexin(Cx) 26\u2010composed gap junctional intercellular communication (GJIC) enhances the intercellular propagation of \u201cdeath signal\u201d, thereby increasing chemotherapeutic cytotoxicity. However, it is unclear whether Cx26\u2010formed GJIC has an effect on PDT phototoxicity. The results in the present study showed that Cx26\u2010composed GJ formation at high density enhances the phototoxicity of Photofrin\u2010PDT. When the Cx26 is not expressed or Cx26 channels are blocked, the phototoxicity in high\u2010density cultures substantially reduces, indicating that the enhanced PDT phototoxicity at high density is mediated by Cx26\u2010composed GJIC. The GJIC\u2010mediated increase in PDT phototoxicity was associated with ROS, calcium and lipid peroxide\u2010mediated stress signaling pathways. The work presents the ability of Cx26\u2010composed GJIC to enhance the sensitivity of malignant cells to PDT, and indicates that maintenance or increase of Cx26\u2010formed GJIC may be a profitable strategy towards the enhancement of PDT therapeutic efficiency. <jats:bold>Picture<\/jats:bold>: The survival response of Photofrin\u2010PDT in Dox\u2010treated (Cx26 expressing, GJ\u2010formed) and Dox\u2010untreated cells (Cx26 non\u2010expressing, GJ\u2010unformed) at high\u2010cell density condition.<\/jats:p>","DOI":"10.1002\/jbio.201600255","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T07:03:02Z","timestamp":1492498982000},"page":"1586-1596","source":"Crossref","is-referenced-by-count":15,"title":["Enhanced phototoxicity of photodynamic treatment by Cx26\u2010composed GJIC via ROS\u2010, calcium\u2010 and lipid peroxide\u2010mediated pathways"],"prefix":"10.1002","volume":"10","author":[{"given":"Deng\u2010Pan","family":"Wu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Pharmacy School of Xuzhou Medical University  Xuzhou City Jiangsu Province 221004 P.R. 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