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In this study, we tested whether Fourier transform infrared (FTIR)\u2010based analysis of blood plasma is sensitive to detect vasoprotective effects of treatment with perindopril including reversal of endothelial dysfunction in diabetes. For this purpose, plasma samples were collected from untreated db\/db mice, db\/db mice treated with 2 or 10\u2009mg\/kg perindopril and db+ mice. The effect of perindopril on endothelial function was examined in ex vivo aortic rings; 10\u2009mg\/kg but not 2\u2009mg\/kg of perindopril reversed endothelial dysfunction. In plasma of db\/db mice, the balance between conformations of plasma proteins was noted, and treatment with perindopril at a high dose but not at a low dose reversed this effect. This was revealed by amide II\/amide I ratio attributed to increased \u03b2\u2010sheet formation. Spectral markers at 3010, 1520\/1238\u2009cm<jats:sup>\u22121<\/jats:sup>, representative for unsaturation degree of lipids and phosphorylation of tyrosine, respectively, were also affected by perindopril treatment. In conclusion, although metabolic abnormalities associated with type 2 diabetes mellitus such as hypertriglyceridemia and hyperglycemia strongly affected spectral FTIR profile of diabetic plasma, we identified FTIR features that seem to be associated with the vasoprotective activity of ACE\u2010I.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201700044-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201700044","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T13:37:31Z","timestamp":1499866651000},"source":"Crossref","is-referenced-by-count":32,"title":["A possible Fourier transform infrared\u2010based plasma fingerprint of angiotensin\u2010converting enzyme inhibitor\u2010induced reversal of endothelial dysfunction in diabetic mice"],"prefix":"10.1002","volume":"11","author":[{"given":"Emilia","family":"Staniszewska\u2010Slezak","sequence":"first","affiliation":[{"name":"Faculty of Chemistry Jagiellonian University  Krakow Poland"},{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Wiercigroch","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Jagiellonian University  Krakow Poland"},{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Fedorowicz","sequence":"additional","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"},{"name":"Chair of Pharmacology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Buczek","sequence":"additional","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Mateuszuk","sequence":"additional","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Baranska","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Jagiellonian University  Krakow Poland"},{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Chlopicki","sequence":"additional","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University  Krakow Poland"},{"name":"Chair of Pharmacology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Malek","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2013"},{"key":"e_1_2_6_3_1","first-page":"792393","author":"Oever I. 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