{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:41:33Z","timestamp":1768070493824,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>There is a need to further improve the clinical care of our most vulnerable patients\u2014preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3\u2010dimensional\u2010printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700\u2010g premature infant. The measurements yield reliable signals for source\u2013detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201700097-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201700097","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:50:14Z","timestamp":1502956214000},"source":"Crossref","is-referenced-by-count":18,"title":["Development of a 3\u2010dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen\u2014Laser\u2010detector position considerations"],"prefix":"10.1002","volume":"11","author":[{"given":"Jim","family":"Larsson","sequence":"first","affiliation":[{"name":"Division of Combustion Physics, Department of Physics Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Physics Lund University  Lund Sweden"},{"name":"GASPOROX AB (publ)  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of Physics Lund University  Lund Sweden"},{"name":"GASPOROX AB (publ)  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Krite Svanberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Anesthesiology and Intensive Care Medicine Sk\u00e5ne University Hospital, Lund University  Lund Sweden"},{"name":"Lund Laser Centre Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Swartling","sequence":"additional","affiliation":[{"name":"GASPOROX AB (publ)  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e4rta","family":"Lewander Xu","sequence":"additional","affiliation":[{"name":"GASPOROX AB (publ)  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Bood","sequence":"additional","affiliation":[{"name":"Division of Combustion Physics, Department of Physics Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Andersson\u2010Engels","sequence":"additional","affiliation":[{"name":"Department of Physics Lund University  Lund Sweden"},{"name":"IPIC Tyndall National Institute, Lee Maltings  Cork Ireland"},{"name":"Department of Physics University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.07.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000297773"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-002-0774-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(13)70008-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2012.08.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2011.643510"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113059"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.844125"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/h11-119"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3156047"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVCE.2007.23.2.65"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.26.000016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lpor.201200073"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100406"},{"key":"e_1_2_7_19_1","volume":"20","author":"Zhang H.","year":"2015","journal-title":"J. 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