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However, the use of PAM has been largely limited to small vertebrates due to the large size\/weight and the inconvenience of the equipment. Here, we describe a portable optical\u2010resolution photoacoustic microscopy (pORPAM) system for 3\u2010dimensional (3D) imaging of small\u2010to\u2010large rodents and humans with a high spatiotemporal resolution and a large field of view. We show extensive applications of pORPAM to multiscale animals including mice and rabbits. In addition, we image the 3D vascular networks of human lips, and demonstrate the feasibility of pORPAM to observe the recovery process of oral ulcer and cancer\u2010associated capillary loops in human oral cavities. This technology is promising for broad biomedical studies from fundamental biology to clinical diseases.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201700250-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201700250","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T11:02:40Z","timestamp":1508842960000},"source":"Crossref","is-referenced-by-count":21,"title":["Portable optical\u2010resolution photoacoustic microscopy for volumetric imaging of multiscale organisms"],"prefix":"10.1002","volume":"11","author":[{"given":"Tian","family":"Jin","sequence":"first","affiliation":[{"name":"School of Physical Electronics University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Physical Electronics University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Physical Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Center for Information in Biomedicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huikai","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabei","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Physical Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Center for Information in Biomedicine University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Medical Engineering University of South Florida  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2598-6801","authenticated-orcid":false,"given":"Lei","family":"Xi","sequence":"additional","affiliation":[{"name":"School of Physical Electronics University of Electronic Science and Technology of China  Chengdu China"},{"name":"Center for Information in Biomedicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1483"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1074"},{"key":"e_1_2_8_4_1","unstructured":""},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2015.29"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2011.0028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2009.157"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3497677"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.001724"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/1612-2011\/11\/4\/045601"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2522"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2015.22"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2721"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.15.012277"},{"key":"e_1_2_8_15_1","volume":"5","author":"De\u00e1nben X.","year":"2016","journal-title":"Light Sci. 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