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Quantification of degree light localization in optical media is widely used for characterizing degree of structural disorder in that media. Recently, this light localization approach was extended to analyze structural changes in biological cell like heterogeneous optical media, with potential application in cancer diagnostics. Confocal fluorescence microscopy was used to construct \u201coptical lattices,\u201d which represents 2\u2010dimensional refractive index map corresponding to the spatial mass density distribution of a selected molecule inside the cell. The structural disorder properties of the selected molecules were evaluated numerically using light localization strength in these optical lattices, in a single parameter called \u201cdisorder strength.\u201d The method showed a promising potential in differentiating cancerous and non\u2010cancerous cells. In this paper, we show that by quantifying submicron scale disorder strength in the nuclear DNA mass density distribution, a wide range of control and cancerous breast and prostate cells at different hierarchy levels of tumorigenicity were correctly distinguished. We also discuss how this photonic technique can be used in examining tumorigenicity level in unknown prostate cancer cells, and potential to generalize the method to other cancer cells.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201700257-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201700257","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T14:46:44Z","timestamp":1512830804000},"source":"Crossref","is-referenced-by-count":12,"title":["Quantification of photonic localization properties of targeted nuclear mass density variations: Application in cancer\u2010stage detection"],"prefix":"10.1002","volume":"11","author":[{"given":"Peeyush","family":"Sahay","sequence":"first","affiliation":[{"name":"BioNanoPhotonics Laboratory, Department of Physics University of Memphis  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Ganju","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and the Center for Cancer Research, College of Pharmacy University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda M.","family":"Almabadi","sequence":"additional","affiliation":[{"name":"BioNanoPhotonics Laboratory, Department of Physics University of Memphis  Memphis Tennessee"},{"name":"Department of Biomedical Engineering University of Memphis  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemendra M.","family":"Ghimire","sequence":"additional","affiliation":[{"name":"BioNanoPhotonics Laboratory, Department of Physics University of Memphis  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali M.","family":"Yallapu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and the Center for Cancer Research, College of Pharmacy University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Skalli","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Integrated Microscopy Center University of Memphis  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Jaggi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and the Center for Cancer Research, College of Pharmacy University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash C.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and the Center for Cancer Research, College of Pharmacy University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1601-3506","authenticated-orcid":false,"given":"Prabhakar","family":"Pradhan","sequence":"additional","affiliation":[{"name":"BioNanoPhotonics Laboratory, Department of Physics University of Memphis  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Molecular Cell Biology","author":"Lodish H.","year":"2000"},{"key":"e_1_2_8_3_1","volume-title":"The Pharmacological Basis of Therapeutics","author":"Bruton L.","year":"2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14258"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(02)00009-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.17.7915"},{"key":"e_1_2_8_7_1","first-page":"286","volume":"87","author":"Doudkine A.","year":"1995","journal-title":"Pathologica"},{"key":"e_1_2_8_8_1","first-page":"323","volume":"17","author":"Beil M.","year":"1995","journal-title":"Anal. 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