{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:31:11Z","timestamp":1781739071763,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"am","delay-in-days":337,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017009566"],"award-info":[{"award-number":["2017009566"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Quantitative phase imaging (QPI) is an emerging modality, which enables the identification of abnormalities in tissue based on optical properties. QPI can be applied to any biological specimen due to its label\u2010free imaging capability, but its use in stained tissue is unclear. Here, we study the variability of QPI with the staining dye. Several tissues such as brain, heart and lung were stained with hematoxylin and eosin, and their optical properties compared at 550 and 730 nm. Our results showed that phase and scattering coefficients varied when QPI was used at the absorption wavelength of the staining dye. We also found that the variation of optical properties was dependent on tissue morphology.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201700402-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201700402","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T06:04:52Z","timestamp":1525413892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of tissue staining in quantitative phase imaging"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6165-824X","authenticated-orcid":false,"given":"Sungbea","family":"Ban","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST)  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Min","sequence":"additional","affiliation":[{"name":"Rowland Institute at Harvard University  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-8773","authenticated-orcid":false,"given":"Yujin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST)  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Popescu","sequence":"additional","affiliation":[{"name":"Quantitative Light Imaging Laboratory, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Urbana Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-3679","authenticated-orcid":false,"given":"Woonggyu","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST)  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"V.Kumar A. K.Abbas J. C.Aster S. L.Robbins Robbins Basic Pathology Elsevier Saunders Amsterdam 2013."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1364\/AOP.6.000057"},{"key":"e_1_2_6_4_1","volume-title":"Quantitative Phase Imaging of Cells and Tissues","author":"Popescu G.","year":"2011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.25.001573"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.001763"},{"key":"e_1_2_6_7_1","first-page":"6","author":"Min E.","year":"2016","journal-title":"Sci. Rep."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2009.2036741"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc50515d"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199413000026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.19.023215"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.028485"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.39.002759"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.47.000A52"},{"key":"e_1_2_6_15_1","first-page":"51","volume-title":"Principles and Techniques of Digital Holographic Microscopy","author":"Kim M. K.","year":"2010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/s130404170"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.1.2.020901"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613204114"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00121.2008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.52.000A97"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.29.002503"},{"key":"e_1_2_6_22_1","first-page":"6","volume-title":"Application of Color Digital Holographic Microscopy for Analysis of Stained Tissue Sections","author":"Mo X.","year":"2009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ib20227a"},{"key":"e_1_2_6_24_1","first-page":"11937","author":"Bettenworth D.","year":"2017","journal-title":"Histol. Histopathol."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.6.066016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31034"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09976"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.35.002840"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3656732"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.9.000921"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3523618"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.31.000775"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.009673"},{"key":"e_1_2_6_34_1","first-page":"1","author":"Edwards C.","year":"2012","journal-title":"Light Sci. Appl."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.18.022637"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.36.001215"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201700402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201700402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.201700402","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jbio.201700402","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201700402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:17:58Z","timestamp":1692472678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201700402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/jbio.201700402"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201700402","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]},"assertion":[{"value":"2017-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e201700402"}}