{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:36:42Z","timestamp":1774625802482,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013270218"],"award-info":[{"award-number":["2013270218"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015249405"],"award-info":[{"award-number":["2015249405"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/24907\u20103"],"award-info":[{"award-number":["2016\/24907\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The use of dermal substitutes to treat skin defects such as ulcers has shown promising results, suggesting a potential role for skin substitutes for treating acute and chronic wounds. One of the main drawbacks with the use of dermal substitutes is the length of time from engraftment to graft take, plus the risk of contamination and failure due to this prolonged integration. Therefore, the use of adjuvant energy\u2010based therapeutic modalities to augment and accelerate the rate of biointegration by dermal substitute engraftments is a desirable outcome. The photobiomodulation (PBM) therapy modulates the repair process, by stimulating cellular proliferation and angiogenesis. Here, we evaluated the effect of PBM on a collagen\u2010glycosaminoglycan flowable wound matrix (FWM) in an ex vivo human skin wound model. PBM resulted in accelerated rate of re\u2010epithelialization and organization of matrix as seen by structural arrangement of collagen fibers, and a subsequent increased expression of alpha\u2010smooth muscle actin (\u03b1\u2010SMA) and vascular endothelial growth factor A (VEGF\u2010A) leading to an overall improved healing process. The use of PBM promoted a beneficial effect on the rate of integration and healing of FWM. We therefore propose that the adjuvant use of PBM may have utility in enhancing engraftment and tissue repair and be of value in clinical practice.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201800077-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201800077","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T13:28:33Z","timestamp":1524576513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Photobiomodulation of a flowable matrix in a human skin ex vivo model demonstrates energy\u2010based enhancement of engraftment integration and remodeling"],"prefix":"10.1002","volume":"11","author":[{"given":"Lia M. G.","family":"Neves","sequence":"first","affiliation":[{"name":"Laboratory of Biology of Aging (LABEN), Department of Gerontology Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivaldo A.","family":"Parizotto","sequence":"additional","affiliation":[{"name":"Physical Therapy Department Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"},{"name":"Biotechnology Post\u2010Graduation Program University of Araraquara  Araraquara Brazil"},{"name":"Post\u2010Graduation in Biomedical Engineering University of Brazil  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-7392","authenticated-orcid":false,"given":"Marcia R.","family":"Cominetti","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of Aging (LABEN), Department of Gerontology Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-6491","authenticated-orcid":false,"given":"Ardeshir","family":"Bayat","sequence":"additional","affiliation":[{"name":"School of Biological Sciences and Health\/Division of Musculoskeletal and Dermatological Sciences University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1016\/S0002-9610(98)00184-6","volume":"176","author":"Stadelmann W. K.","year":"1998","journal-title":"Am. J. Surg."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161025476"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.07.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0345"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1938640009333474"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/10\/4\/041001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.09.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2080-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201600176"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552011000300009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/950347"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2012.05.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.184"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12133.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1987.tb00510.x"},{"key":"e_1_2_8_18_1","first-page":"301","volume":"7","author":"Darby I. A.","year":"2014","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1289-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm809"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2010.07.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.06.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.04.059"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201800077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201800077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:11:24Z","timestamp":1694859084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201800077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jbio.201800077"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201800077","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]},"assertion":[{"value":"2018-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e201800077"}}