{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:58:26Z","timestamp":1762955906519,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["NSC 105-2221-E-009-108-MY3","NSC 106-2923-E-009-002-MY2","NSC 106-2811-E-009-023","NSC 105-2221-E-009-183-MY3","NSC 105-2811-E-009-028","NSC 106-2622-E-009-012-CC3"],"award-info":[{"award-number":["NSC 105-2221-E-009-108-MY3","NSC 106-2923-E-009-002-MY2","NSC 106-2811-E-009-023","NSC 105-2221-E-009-183-MY3","NSC 105-2811-E-009-028","NSC 106-2622-E-009-012-CC3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain and a heightened response to pressure. Most medical researches pointed out that FM patients with endothelial dysfunction and arterial stiffness. A continuous\u2010wave near\u2010infrared spectroscopy (NIRS) system is used in present study to measure the hemodynamic changes elicited by breath\u2010holding task in patients with FM. Each patient completed a questionnaire survey including demographics, characteristics of body pain, associated symptoms, headache profiles and Hospital Anxiety and Depression Scale. A total of 27 FM patients and 26 health controls were enrolled. In comparison with healthy controls, patients with FM showed lower maximal and averaged change of oxyhemoglobin concentration in both the left (1.634\u2009\u00b10.890 and 0.810\u2009\u00b10.525\u2009\u03bcM) and the right (1.576\u2009\u00b10.897 and 0.811\u2009\u00b10.601\u2009\u03bcM) prefrontal cortex than healthy controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05 for both sides) during the breath\u2010holding task. In conclusion, FM is associated with altered cerebrovascular reactivity measured by NIRS and breath\u2010holding task, which may reflect endothelial dysfunction or arterial stiffness. Oxygenated hemoglobin concentration changes of healthy controls and FM patients.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201800142-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201800142","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T07:19:32Z","timestamp":1530170372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Altered near\u2010infrared spectroscopy response to breath\u2010holding in patients with fibromyalgia"],"prefix":"10.1002","volume":"12","author":[{"given":"Wei\u2010Ta","family":"Chen","sequence":"first","affiliation":[{"name":"Neurological Institute, Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan\u2010Hsiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Biomedical Optical Imaging Lab, Department of Photonics, College of Electrical and Computer Engineering National Chiao Tung University Hsinchu City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-8019","authenticated-orcid":false,"given":"Chia\u2010Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Biomedical Optical Imaging Lab, Department of Photonics, College of Electrical and Computer Engineering National Chiao Tung University Hsinchu City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.91794"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100594"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-013-0356-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21896"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.11.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.12.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.02.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005224"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.02.022"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.093245"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01132-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09868-w"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1227"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-3-16"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2014.0274"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1769"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.049"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0098-07.2007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.014"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0505"},{"key":"e_1_2_7_26_1","first-page":"1233","volume":"20","author":"Kastrup A.","year":"1999","journal-title":"Am. 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