{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:06:59Z","timestamp":1792782419211,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IZKF","award":["Core Unit PIX"],"award-info":[{"award-number":["Core Unit PIX"]}]},{"name":"Medical Faculty of the University of Muenster","id":[{"id":"https:\/\/ror.org\/00pd74e08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    The study aimed to evaluate the clinical feasibility of hybrid ultrasound\/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US\/MSOT imaging system was applied for imaging patients diagnosed with SSc (\n                    <jats:italic>n<\/jats:italic>\n                    = 7) and healthy volunteers (\n                    <jats:italic>n<\/jats:italic>\n                    = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO\n                    <jats:sub>2<\/jats:sub>\n                    ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one\u2010way nested analysis of variance, Tukey post\u2010hoc test as well as student's\n                    <jats:italic>t<\/jats:italic>\n                    test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO\n                    <jats:sub>2<\/jats:sub>\n                    (26.16\u2009\u00b1 0.71 vs 38.2 \u00b1 1.54,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.023) and HbT (55.92\u2009\u00b1 1.62 vs 72.46\u2009\u00b1 1.90,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non\u2010invasively and monitor early therapy response.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201800155-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.201800155","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T01:23:11Z","timestamp":1530753791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Multispectral optoacoustic tomography of systemic sclerosis"],"prefix":"10.1002","volume":"11","author":[{"given":"Max","family":"Masthoff","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Helfen","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Claussen","sequence":"additional","affiliation":[{"name":"iThera Medical  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Roll","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos","family":"Karlas","sequence":"additional","affiliation":[{"name":"Institute for Biological and Medical Imaging Technical University Munich\/Helmholtz Zentrum Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidemarie","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Gabri\u00ebls","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Riess","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Heindel","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00e4fers","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Muenster  M\u00fcnster Germany"},{"name":"European Institute for Molecular Imaging, University Hospital Muenster  M\u00fcnster Germany"},{"name":"DFG EXC 1003 Cluster of Excellence \u2018Cells in Motion\u2019 University of Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Ntziachristos","sequence":"additional","affiliation":[{"name":"Institute for Biological and Medical Imaging Technical University Munich\/Helmholtz Zentrum Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Eisenbl\u00e4tter","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster  M\u00fcnster Germany"},{"name":"Division of Imaging Sciences &amp; Biomedical Engineering King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gerth","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D University Hospital Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7228-6963","authenticated-orcid":false,"given":"Moritz","family":"Wildgruber","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster  M\u00fcnster Germany"},{"name":"DFG EXC 1003 Cluster of Excellence \u2018Cells in Motion\u2019 University of Muenster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew047"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205897"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.12.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159611"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1074"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152160"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.003395"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5002-x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-3200"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0573"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad1278"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1612455"},{"key":"e_1_2_6_16_1","first-page":"1453272","volume":"2016","author":"Liu Y.","year":"2016","journal-title":"Biomed. 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