{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:44:05Z","timestamp":1790685845301,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Mutations in <jats:italic>NCSTN<\/jats:italic> gene (encoding for nicastrin protein) are associated with hidradenitis suppurativa (HS), a chronic inflammatory disease involving hair follicles. HS is clinically handled with drugs but the most severe cases are treated with surgery. Photobiomodulation (PBM) therapy, already used in the treatment of skin diseases such as acne, herpes virus lesions, ultraviolet damage, vitiligo, hypertrophic scar, keloid, burn, psoriasis and diabetic chronic wounds, could be beneficial as an adjuvant supportive treatment to promote and foster the healing process after skin excision in HS. The effects of PBM therapy in promoting the wound closure are evaluated in a HaCaT cells <jats:italic>NCSTN<\/jats:italic>\u2212<jats:italic>\/<\/jats:italic>\u2212, assessing cell metabolism, migration rate, proliferation and cell cycle progression. In our experimental model, PBM exerts a potent action on metabolism of mutated keratinocytes, incrementing adenosine triphosphate (ATP) production at 2 hours, while after 24\u2009hours an increase of metabolism with a decrement of intracellular ATP levels were recorded. Moreover, PBM speeds up the wound closure, inducing cells' migration without affecting their proliferation.Based on our findings, we suggest the use of PBM in HS patients, who undergo major surgery with large skin excision.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201800174-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201800174","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T05:03:17Z","timestamp":1530594197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-4126","authenticated-orcid":false,"given":"Paola M.","family":"Tricarico","sequence":"first","affiliation":[{"name":"University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Zupin","sequence":"additional","affiliation":[{"name":"University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Pacor","sequence":"additional","affiliation":[{"name":"University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francette","family":"Jean\u2010Louis","sequence":"additional","affiliation":[{"name":"INSERM U955 Eq.16 Institut Mondor de Recherche Biom\u00e9dicale and VRI (Vaccine Research Institute)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Boniotto","sequence":"additional","affiliation":[{"name":"INSERM U955 Eq. 16 Institut Mondor de Recherche Biom\u00e9dicale and Universit\u00e9 Paris Est\u2010Cr\u00e9teil (UPEC), Facult\u00e9 de M\u00e9decine  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[{"name":"University of Trieste  Trieste Italy"},{"name":"Institute for Maternal and Child Health \"Burlo Garofolo\"  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540300700109"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13211"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.051"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00087.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02616510"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14464"},{"key":"e_1_2_7_8_1","first-page":"330","volume":"19","author":"Wang B.","year":"2010","journal-title":"Science"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14223"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.07.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000187"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2907"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15226"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.09.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228334"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228337"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000080"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2005.07.19.43.59.c3906"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.020"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734615598890"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12544"},{"key":"e_1_2_7_22_1","first-page":"41","volume":"32","author":"Avci P.","year":"2013","journal-title":"Semin. 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