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Fourier\u2010transform infrared (FTIR) and Raman spectroscopies are capable of noninvasively and accurately capturing the biochemical properties of biological tissue from its pathological status. Our aim was to probe critial biomolecular changes of liver accompanying the progression of pure foetal hepatoblastoma (PFH) by FTIR and Raman spectroscopies. Herein, biochemical alterations were both evident in the FTIR spectra (regions of 3100\u20102800\u2009cm<jats:sup>\u22121<\/jats:sup> and 1800\u2010900\u2009cm<jats:sup>\u22121<\/jats:sup>) and the Raman spectra (region of 1800\u2010400\u2009cm<jats:sup>\u22121<\/jats:sup>) among normal, borderline and malignant liver tissues. Compared with normal tissues, the ratios of protein\u2010to\u2010lipid, <jats:italic>\u03b1\u2010<\/jats:italic>helix\u2010to\u2010<jats:italic>\u03b2<\/jats:italic>\u2010sheet, RNA\u2010to\u2010DNA, CH3 methyl\u2010to\u2010CH2 methylene, glucose\u2010to\u2010phospholipids, and unsaturated\u2010to\u2010saturated lipids intensities were significantly higher in malignant tissues, while the ratios of RNA\u2010to\u2010Amide II, DNA\u2010to\u2010Amide II, glycogen\u2010to\u2010cholesterol and Amide I\u2010to\u2010Amide II intensities were remarkably lower. These biochemical alterations in the transition from normal to malignant have profound implications not only for cyto\u2010pathological classification but also for molecular understanding of PFH progression. The successive changes of the spectral characteristics have been shown to be consistent with the development of PFH, indicating that FTIR and Raman spectroscopies are excellent tools to interrogate the biochemical features of different grades of PFH.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201800304-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201800304","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T01:59:59Z","timestamp":1555466399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fourier transform infrared and Raman\u2010based biochemical profiling of different grades of pure foetal\u2010type hepatoblastoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Peng","family":"Duan","sequence":"first","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Center for Reproductive Medicine, Xiangyang No. 1 People's Hospital Hubei University of Medicine  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyingxue","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiandong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Taihe Hospital Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manman","family":"Long","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuge","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunling","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo L.M.","family":"Morais","sequence":"additional","affiliation":[{"name":"Lancashire Teaching Hospitals NHS Trust  Preston UK"},{"name":"Biocel Ltd  Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis L.","family":"Martin","sequence":"additional","affiliation":[{"name":"Lancashire Teaching Hospitals NHS Trust  Preston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbin","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dameng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengliang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Center for Reproductive Medicine Wuhan Tongji Reproductive Medicine Hospital  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1018","volume":"18","author":"Zhang Y.","year":"2014","journal-title":"Eur. 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