{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:11:17Z","timestamp":1759057877901,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>An improved method, where conventional otoscope investigation of human suspicious otitis media is combined with diffuse reflectance spectroscopy and gas in scattering media absorption spectroscopy (GASMAS) is being developed. Otitis media is one of the most common infectious diseases in children, whose Eustachian tube connecting the middle ear with the nasal cavity is more horizontal than for adults, which leads to impaired fluid drainage. At present, the use of an otoscope to visually observe possible changes in the tympanic membrane appearance is the main diagnostics method for otitis media. Inaccurate diagnosis related to similar symptoms, and the difficulty for small children to describe the condition experienced, frequently leads to over\u2010prescription of antibiotics and alarming increase in bacterial resistance development. More accurate diagnostic methods are highly desirable. Diffuse reflectance spectroscopy is a non\u2010invasive quantitative spectroscopic technique that enables to objectively quantify changes in the hemoglobin content of the tympanic membrane related to inflammation. If an infection is present, the ventilatory function of the Eustachian tube is frequently impaired and the middle\u2010ear cavity will be filled with fluid. GASMAS, a non\u2010invasive detection method, can non\u2010invasively determine if gas is replaced by fluid in the middle\u2010ear cavity.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201800305-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201800305","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T12:21:57Z","timestamp":1549369317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Towards an optical diagnostic system for otitis media using a combination of otoscopy and spectroscopy"],"prefix":"10.1002","volume":"12","author":[{"given":"Lingna","family":"Hu","sequence":"first","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wansha","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Lin","sequence":"additional","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Svanberg","sequence":"additional","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"},{"name":"Lund Laser Center Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-6972","authenticated-orcid":false,"given":"Sune","family":"Svanberg","sequence":"additional","affiliation":[{"name":"Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"},{"name":"Lund Laser Center Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"volume-title":"Otitis Media in Infants and Children","year":"2007","author":"Bluestone C. D.","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-009-9008-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.17-6-191"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199806000-00033"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199806000-00036"},{"key":"e_1_2_8_7_1","unstructured":"S. A.BoppartandChuanwuXi Device and method for imaging the ear using optical coherence tomography United States Patent Pub. No.: US 20090185191A1(2009)."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/25\/6\/012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.26.000016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lpor.201200073"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2777189"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7248\/jjrhi.50.26"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.12.127005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.267"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201600229"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.5.057001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.54.002234"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00340-008-3171-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sca.4950100403"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-45524-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3663211"},{"issue":"224","key":"e_1_2_8_22_1","first-page":"452","volume":"63","author":"Ingelstedt S.","year":"1966","journal-title":"Acta Otolaryngol."},{"issue":"2","key":"e_1_2_8_23_1","first-page":"161","volume":"85","author":"Elner A.","year":"1975","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199806000-00039"},{"key":"e_1_2_8_25_1","first-page":"CD004401","volume":"4","author":"Leach A. J.","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3488"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201800305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201800305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.201800305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201800305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:09:58Z","timestamp":1693908598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201800305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,28]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jbio.201800305"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201800305","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"type":"print","value":"1864-063X"},{"type":"electronic","value":"1864-0648"}],"subject":[],"published":{"date-parts":[[2019,2,28]]},"assertion":[{"value":"2018-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e201800305"}}