{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:34:10Z","timestamp":1773268450205,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002644","name":"Pukyong National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002644","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Preservation of the parathyroid gland (PTG) in neck endocrine surgery is important for regulating the amount of calcium in the blood and within the bones. Localization of the PTG has been attempted using various methods such as ultrasound, sestamibi, computerized tomography, magnetic resonance imaging and indocyanine green fluorescence imaging. These methods cannot be used during surgery, have high sensitivity or have PTG specificity. However, autofluorescence technique has shown high sensitivity and does not require exogenous contrast. In this study, a new optical system was designed and developed into a clinical system. The system enabled easier and faster focusing on the surgical area and high\u2010resolution video imaging while maintaining a clear image. The system was located above the head of the surgeon. The surgeon was able to see the real\u2010time autofluorescent image on the monitor next to the operating table at any time to locate the PTG. The PTG buried in the adipose tissue and connective tissue was located easily and accurately. The clinical trial conducted in this study consisted of 56 parathyroid cases in 26 patients. For the statistical results, the sensitivity and accuracy in this redesigned autofluorescent imaging system were 98.1% and 96.4%, respectively.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201900017-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201900017","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T13:33:53Z","timestamp":1565703233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Video\u2010assisted parathyroid gland mapping with autofocusing"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-7533","authenticated-orcid":false,"given":"Yikeun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Center for Marine\u2010Integrated Biomedical Technology Pukyong National University  Busan South Korea"},{"name":"Innovative Biomedical Technology Research Center  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Innovative Biomedical Technology Research Center  Busan South Korea"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kosin University College of Medicine  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Dae","family":"Lee","sequence":"additional","affiliation":[{"name":"Innovative Biomedical Technology Research Center  Busan South Korea"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kosin University College of Medicine  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-4813","authenticated-orcid":false,"given":"Yeh\u2010Chan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Center for Marine\u2010Integrated Biomedical Technology Pukyong National University  Busan South Korea"},{"name":"Innovative Biomedical Technology Research Center  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-017-0502-0"},{"key":"e_1_2_7_3_1","first-page":"225","volume":"25","author":"Allahverdi T.","year":"2018","journal-title":"J. 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