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Short wavelengths, perceived as blue color, are the strongest synchronizing agent for the circadian system that keeps most biological and psychological rhythms internally synchronized. Circadian rhythm is important for optimum function of organisms and circadian sleep\u2013wake disruptions or chronic misalignment often may lead to psychiatric and neurodegenerative illness. The beneficial effect on circadian synchronization, sleep quality, mood, and cognitive performance depends not only on the light spectral composition but also on the timing of exposure and its intensity. Exposure to blue light during the day is important to suppress melatonin secretion, the hormone that is produced by the pineal gland and plays crucial role in circadian rhythm entrainment. While the exposure to blue is important for keeping organism's wellbeing, alertness, and cognitive performance during the day, chronic exposure to low\u2010intensity blue light directly before bedtime, may have serious implications on sleep quality, circadian phase and cycle durations. This rises inevitably the need for solutions to improve wellbeing, alertness, and cognitive performance in today's modern society where exposure to blue light emitting devices is ever increasing.<\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201900102-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1002\/jbio.201900102","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T11:35:39Z","timestamp":1566387339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":267,"title":["The inner clock\u2014Blue light sets the human rhythm"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-6711","authenticated-orcid":false,"given":"Siegfried","family":"Wahl","sequence":"first","affiliation":[{"name":"Institute for Ophthalmic Research University of Tuebingen  Tuebingen Germany"},{"name":"Carl Zeiss Vision International GmbH  Aalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research University of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schaupp","sequence":"additional","affiliation":[{"name":"Carl Zeiss Vision International GmbH  Aalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lappe","sequence":"additional","affiliation":[{"name":"Carl Zeiss Vision International GmbH  Aalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliya V.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research University of Tuebingen  Tuebingen Germany"},{"name":"Carl Zeiss Vision International GmbH  Aalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/1539108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.1.340"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn768"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067262"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00130-9"},{"key":"e_1_2_10_7_1","volume-title":"Neuronal Input Pathways to the Brain's Biological Clock and Their Functional Significance","author":"Hannibal J.","year":"2006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.07.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/415493a"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008836"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-233098"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032100"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520601139805"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00128"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01342701"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.015"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135821"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00282-X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)53020-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013097"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/5.11.3"},{"key":"e_1_2_10_22_1","first-page":"59","volume":"162","author":"Pickard G. 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