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In the study, thrombus was induced in the femoral vein of mice by FeCl<jats:sub>3<\/jats:sub> and monitored over time by spectral\u2010domain optical coherence tomography (OCT). Three\u2010dimensional images of thrombi with or without heparin as an antithrombotic agent were obtained from OCT angiography. In addition, several parameters of thrombi were analyzed and compared between control and anticoagulant groups. By using OCT, we were able to trace thrombus generation in the same mouse in real time. We found that in our model heparin reduced thrombus size by ~60% and thrombus cross\u2010sectional area by 50%. OCT results also show that both time to thrombus size (&gt;0.02mm<jats:sup>3<\/jats:sup>) and time to occlusion (&gt;30%) were significantly reduced after heparin addition. This study demonstrates that OCT reliably monitors thrombus generation and progression from various aspects including thrombus size. This enables us to measure the kinetic of thrombosis more accurately, and effectively evaluate the efficacy and activities of antithrombotic drugs. This model may represent a useful tool in antithrombotic drug discoveries in preclinical studies.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201900105-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201900105","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T15:05:08Z","timestamp":1563980708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vivo monitoring of thrombosis in mice by optical coherence tomography"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9754-5597","authenticated-orcid":false,"given":"Yao","family":"Yu","sequence":"first","affiliation":[{"name":"School of Control Engineering Northeastern University at Qinhuangdao  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghan","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Control Engineering Northeastern University at Qinhuangdao  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Control Engineering Northeastern University at Qinhuangdao  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Sino\u2010Dutch Biomedical and Information Engineering Northeastern University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Hospital of Qinhuangdao  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Control Engineering Northeastern University at Qinhuangdao  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhe","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Control Engineering Northeastern University at Qinhuangdao  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1311-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-06-0530"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801082"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306823"},{"key":"e_1_2_6_6_1","first-page":"e54479","volume":"115","author":"Li W.","year":"2016","journal-title":"J. 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