{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:07:43Z","timestamp":1790222863676,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B03033219"],"award-info":[{"award-number":["2017R1D1A1B03033219"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A certain degree of noise can cause hearing problems without a permanent change in the hearing threshold, which is called hidden hearing loss and results from partial loss of auditory synapses. Photobiomodulation (PBM) enhances neural growth and connections in the peripheral nervous systems. In this study, we assessed whether PBM could rescue cochlear synaptopathy after acoustic overexposure in rat. PBM was performed for 7 days after noise exposure. The auditory brainstem responses (ABRs) were acquired before and after noise exposure using a tone and a paired\u2010click stimulus. Auditory response to paired click sound with short time interval was performed to evaluate auditory temporal processing ability. In the result, hearing threshold recovered 2 weeks after noise exposure in both groups. Peak wave 1 amplitude of the ABR and ABR recovery threshold did not recover in the noise only group, whereas it fully recovered in the noise + PBM group. The number of synaptic ribbons was significantly different in the control and noise only groups, while there was no difference between the control and noise + PBM group. These results indicate that PBM rescued peak wave 1 amplitude and maintained the auditory temporal processing ability resulting from a loss of synaptic ribbons after acoustic overexposure.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201900145-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201900145","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T03:53:28Z","timestamp":1561521208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Photobiomodulation using low\u2010level 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2317-9958","authenticated-orcid":false,"given":"Jae\u2010Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Beckman Laser Institute Korea College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Interdiscriplinary Program for Medical Laser, College of Medicine, Dankook University  Cheonan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute Korea College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Interdiscriplinary Program for Medical Laser, College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Department of Otolaryngology Head and Neck Surgery Dankook University Hospital  Cheonan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil\u2010Sang","family":"Chung","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute Korea College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Interdiscriplinary Program for Medical Laser, College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Department of Otolaryngology Head and Neck Surgery Dankook University Hospital  Cheonan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yun","family":"Jung","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute Korea College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Interdiscriplinary Program for Medical Laser, College of Medicine, Dankook University  Cheonan South Korea"},{"name":"Department of Otolaryngology Head and Neck Surgery Dankook University Hospital  Cheonan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.393460"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.02.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2013"},{"issue":"25","key":"e_1_2_6_6_1","first-page":"200","volume":"6","author":"Song Q.","year":"2016","journal-title":"Sci. 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