{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:12:27Z","timestamp":1771330347906,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel photonic method for remote monitoring of task\u2010related hemodynamic changes in human brain activation is presented. Physiological processes associated with neural activity, such as nano\u2010vibrations due to blood flow and tissue oxygenation in the brain, are detected by remote sensing of nano\u2010acoustic vibrations using temporal spatial analysis of defocused self\u2010interference random patterns. Temporal nanometric changes of the speckle pattern due to visual task\u2010induced hemodynamic responses were tracked by this method. Reversing visual checkerboard stimulation alternated with rest epochs, and responsive signals were identified in occipital lobe using near\u2010infrared spectroscopy. Temporal vibrations associated with these hemodynamic response functions were observed using three different approaches: (a) single spot illumination at active and control areas simultaneously, (b) subspots cross\u2010correlation\u2010based analysis, and (c) multiwavelength measurement using a magnitude\u2010squared wavelet coherence function. Findings show remote sensing of task\u2010specific neural activity in the human brain.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio201900201-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.201900201","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T12:35:24Z","timestamp":1565872524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Remote photonic sensing of cerebral hemodynamic changes via temporal spatial analysis of acoustic vibrations"],"prefix":"10.1002","volume":"13","author":[{"given":"Nisan","family":"Ozana","sequence":"first","affiliation":[{"name":"Faculty of Engineering Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"},{"name":"The Bar\u2010Ilan Institute of Nanotechnology and Advanced Materials Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack Adam","family":"Noah","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven 06511 Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven 06511 Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumie","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven 06511 Connecticut"},{"name":"Health Science and Medical Engineering Laboratory, Department of Physiology and Neuroscience, School of Science and Technology Meiji University  Kawasaki\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven 06511 Connecticut"},{"name":"Department of Neuroscience Yale School of Medicine  New Haven 06511 Connecticut"},{"name":"Department of Comparative Medicine Yale School of Medicine  New Haven 06511 Connecticut"},{"name":"Department of Medical Physics and Biomedical Engineering University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeev","family":"Zalevsky","sequence":"additional","affiliation":[{"name":"Faculty of Engineering Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"},{"name":"The Bar\u2010Ilan Institute of Nanotechnology and Advanced Materials Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.929199"},{"key":"e_1_2_9_3_1","first-page":"240","volume":"7","author":"Villringer A.","year":"1995","journal-title":"Cerebrovasc. Brain Metab. Rev."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01132-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.049"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1932552100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.811"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-009-9305-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200010000-00005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep299"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199804000-00013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92418-X"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0657"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00311-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/25\/4\/003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.4.688"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/MEMB.2006.1657788"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/6\/5\/055007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.07.076"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6756"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSA.66.001145"},{"key":"e_1_2_9_22_1","first-page":"9","volume-title":"Laser Speckle and Related Phenomena","author":"Goodman J. W.","year":"1975"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.66"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.021566"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2014.2385793"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3505008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.57.000B45"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.6.065001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00345-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.55.004005"},{"key":"e_1_2_9_31_1","first-page":"968916","volume-title":"Remote Optical Configuration of Pigmented Lesion Detection and Diagnosis of Bone Fractures, Society of Photo\u2010Optical Instrumentation Engineers (SPIE), Bellingham, Washington","author":"Ozana N.","year":"2016"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl050074e"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optcom.2010.06.059"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2804899"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.058"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_9_37_1","first-page":"e52116","volume":"100","author":"Noah J. A.","year":"2015","journal-title":"J. Vis. Exp."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.06.018"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1995.1252"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu320"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.124"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.018"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.036"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.3.1.015004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201700208"}],"container-title":["Journal of Biophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbio.201900201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201900201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbio.201900201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbio.201900201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:54:52Z","timestamp":1694152492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201900201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jbio.201900201"],"URL":"https:\/\/doi.org\/10.1002\/jbio.201900201","archive":["Portico"],"relation":{},"ISSN":["1864-063X","1864-0648"],"issn-type":[{"value":"1864-063X","type":"print"},{"value":"1864-0648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"2019-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e201900201"}}