{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:21:33Z","timestamp":1792466493408,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772044"],"award-info":[{"award-number":["81772044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac optogenetics facilitates the painless manipulation of the heart with optical energy and was recently shown to terminate ventricular tachycardia (VT) in explanted mice heart. This study aimed to evaluate the optogenetic\u2010based termination of induced VT under ischemia in an open\u2010chest rat model and to develop an optimal, optical\u2010manipulation procedure. VT was induced by burst stimulation after ligation of the left anterior descending coronary artery, and the termination effects of the optical manipulation, including electrical anti\u2010tachycardia pacing (ATP) and spontaneous recovery, were tested. Among different multisegment optical modes, four repeated illuminations of 1000\u2009ms in duration with 1\u2010second interval at a 20\u2010times intensity threshold on the right ventricle achieved the highest termination rate of 86.14%\u2009\u00b1\u20094.145%, higher than that achieved by ATP and spontaneous termination. We demonstrated that optogenetic\u2010based cardioversion is feasible and effective in vivo, with the underlying mechanism involving the light\u2010triggered, ChR2\u2010induced depolarization of the illuminated myocardium, in turn generating an excitation that disrupts the preexisting reentrant wave front.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000003-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000003","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T07:26:45Z","timestamp":1585985205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Optogenetic approaches for termination of ventricular tachyarrhythmias after myocardial infarction in rats in vivo"],"prefix":"10.1002","volume":"13","author":[{"given":"Yue","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Cardiology 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