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Yet, intraocular pressure (IOP) measurements for glaucoma monitoring remain an urgent unmet need. Here, we present the integration of a fiber\u2010optic Fabry\u2010Perot pressure sensor with an FDA\u2010approved keratoprosthesis for real\u2010time IOP measurements using a novel strategy based on optical\u2010path self\u2010alignment with micromagnets. Additionally, an alternative noncontact sensor\u2010interrogation approach is demonstrated using a bench\u2010top optical coherence tomography system. We show stable pressure readings with low baseline drift (&lt;2.8\u2009mm\u2009Hg) for &gt;4.5\u2009years in vitro and efficacy in IOP interrogation in vivo using fiber\u2010optic self\u2010alignment, with good initial agreement with the actual IOP. Subsequently, IOP drift in vivo was due to retroprosthetic membrane (RPM) formation on the sensor secondary to surgical inflammation (more severe in the current pro\u2010fibrotic rabbit model). This study paves the way for clinical adaptation of optical pressure sensors with ocular implants, highlighting the importance of controlling RPM in clinical adaptation.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jbio202000031-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1002\/jbio.202000031","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T07:27:20Z","timestamp":1585985240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Implantable self\u2010aligning fiber\u2010optic optomechanical devices for in vivo intraocular pressure\u2010sensing in artificial cornea"],"prefix":"10.1002","volume":"13","author":[{"given":"Pui\u2010Chuen","family":"Hui","sequence":"first","affiliation":[{"name":"Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Shtyrkova","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology  Cambridge Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoniao","family":"Chen","sequence":"additional","affiliation":[{"name":"Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chodosh","sequence":"additional","affiliation":[{"name":"Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"},{"name":"Disruptive Technology Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes H.","family":"Dohlman","sequence":"additional","affiliation":[{"name":"Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-4452","authenticated-orcid":false,"given":"Eleftherios I.","family":"Paschalis","sequence":"additional","affiliation":[{"name":"Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"},{"name":"Disruptive Technology Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology Harvard Medical School  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"M. 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